Carbohydrates play essential roles in nature, such as cell–cell communication, cell growth and immunoresponse. However, the synthesis of structurally well-defined carbohydrates, especially large-sized glycans, is a challenging task. Here we report an automated solution-phase multiplicative complex glycans enabled by preactivation-based, multicomponent, one-pot glycosylation continuous multiplyi...

Final Report: Role of Chain Microstructure and Branching on Solution and Thin Film Phase Behavior Report Title This study has focused on elucidating links between topological design of block copolymers and chain stiffness, their assembly in solution and organization in thin films. Novel aspects include the ability to tune chain rigidity without altering chemical composition and precision contro...

Propargyl esters are employed as effective protecting groups for the carboxyl group during solution-phase peptide synthesis. The propargyl ester groups can be introduced onto free amino acids by treating them with propargyl alcohol saturated with HCl. The reaction between propargyl groups and tetrathiomolybdate is exploited to deblock the propargyl esters. The removal of the propargyl group wit...