conclusions our findings introduced a novel therapeutic effect of diet therapy on circulating mirnas in obese patients with t2dm. mir-33b is an important therapeutic target in the treatment and prevention of t2dm and its complications. results the circulating levels of mir-29a and mir-33b in the diabetic women were higher (0.40-fold) and lower (1.43-fold), respectively, than normal levels. diet...

background: the use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary embolism (pte) remains controversial. we, therefore, conducted this study to compare the effect of thrombolytic plus anticoagulation versus anticoagulation alone on early death and adverse outcome following submassive pte. methods: w e conducted a study of patients with...

neuroinflammation has a significant role in induce of multiple sclerosis (ms) many approaches have been used to treat ms, but none of these methods have not been able to fully improve. one of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuro...

objective: despite the discovery of new antipsychotic drugs in recent years, a number of schizophrenic patients show no response to such drugs and are considered treatment-resistant. in such cases, clozapine and occasionally ect or a combination of drugs are used, though they are not very effective. in recent years, the combination of clozapine and ect for treatment-resistant schizophrenic pati...

new cancer therapies with novel mechanisms and functions are needed to treat patients with different cancers. virotherapy is a good scenario for such treatment. the advantages of virotherapy include the potential lack of cross resistance with standard therapies and the ability to cause tumor destruction by numerous mechanisms. oncolytic virus not only possesses unique mechanisms of action that ...

objectives: the purpose of this study was to investigate the effectiveness of life review therapy on depression reduction of elder women of yazd. methods & materials: method of the research was semi-experimental design by pre-post test with a control group. research population consisted of the elder women who were nursing home residents in yazd. the fateme_alzahra nursing home of taft was rando...

ethics are related to the structure and culture of the society. in addition to specialized ethics for every profession, individuals also hold their own personal beliefs and values. this study aimed to investigate iranian occupational therapists’ perception of ethical practice when working with children. for this purpose, qualitative content analysis was used and semi-structured interviews were ...

conclusion the results of this study show that adding mbct to pharmacotherapy in treatment of dysthymic patients can cause significant improvement in depression symptoms and mindfulness skills in patients compared to pharmacotherapy alone. results in this study, no statistically significant differences were found between the two groups regarding the demographic characteristics. the mean differe...

acceptance and commitment therapy (act) is a new development within behavioral therapy. its goal is to promote psychological flexibility. numerous studies show that suffering results when people attempt to avoid their inner experiences (experiential avoidance). this experiential avoidance often leads to rigid and inflexible behavior that also leads them to compromise their goals and what is imp...

although some childhood fairs and anxieties are as part of normal development in children, but relatively stable over time and may have some anxiety problems in adolescence and adulthood continue to increase. this study is done to determine the effectiveness of cbt (which was included: relaxation, visualization ideally, self-ordering in maykenbam way, thinking-stop of anxiety in wolpe way and c...