November 21, 2016 Title Bayesian Robust Inference for Differential Gene Expression Version 1.38.0 Author Raphael Gottardo Description Test for differentially expressed genes with microarray data. This package can be used with both cDNA microarrays or Affymetrix chip. The packge fits a robust Bayesian hierarchical model for testing for differential expression. Outliers are modeled explicitly usi...

May 15, 2015 Type Package Title Evaluation of Surrogate Endpoints in Clinical Trials Version 0.1-6 Date 2015-05-14 Author Wim Van der Elst, Ariel Alonso & Geert Molenberghs Maintainer Wim Van der Elst Description In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to m...

December 22, 2016 Type Package Title Time-course differential gene expression data analysis using spline regression models followed by gene association network reconstruction Version 1.2.0 Date 2016-10-05 Author Agata Michna Maintainer Herbert Braselmann Depends R (>= 3.3), Biobase, igraph, limma, GSEABase, gtools, splines, GeneNet (>= 1.2.13), longitudinal (>= 1...

April 25, 2017 Title Bayesian Robust Inference for Differential Gene Expression Version 1.40.0 Author Raphael Gottardo Description Test for differentially expressed genes with microarray data. This package can be used with both cDNA microarrays or Affymetrix chip. The packge fits a robust Bayesian hierarchical model for testing for differential expression. Outliers are modeled explicitly using ...

January 31, 2017 Type Package Title Empirical Bayesian approach to mutational signature discovery Version 1.0.1 Author Rafael Rosales, Rodrigo Drummond, Renan Valieris, Israel Tojal da Silva Maintainer Renan Valieris Description The signeR package provides an empirical Bayesian approach to mutational signature discovery. It is designed to analyze single nu...

While the way we build software affects significantly its maintenance in terms of the effort and cost, the experience level of the maintainer in a software acquirers’ organization is also one of concern. In this context, often the maintainer is the user of the system. Unfortunately, it is quite possible to lose the trustworthiness of the software due to the inexperience of the maintainer, espec...

PURPOSE To investigate the optimal strategy for surgical management of traumatic cataract with posterior capsular rupture. METHODS We describe four cases of traumatic cataract with posterior capsular rupture and an in vitro model built to evaluate the optimal infusion pressure during surgery. RESULTS All patients underwent cataract surgery. By using an anterior chamber maintainer to elevate...

March 22, 2017 Title Bayesian Robust Inference for Differential Gene Expression Version 1.38.0 Author Raphael Gottardo Description Test for differentially expressed genes with microarray data. This package can be used with both cDNA microarrays or Affymetrix chip. The packge fits a robust Bayesian hierarchical model for testing for differential expression. Outliers are modeled explicitly using ...

March 23, 2017 Type Package Title Time-course differential gene expression data analysis using spline regression models followed by gene association network reconstruction Version 1.2.0 Date 2016-10-05 Author Agata Michna Maintainer Herbert Braselmann Depends R (>= 3.3), Biobase, igraph, limma, GSEABase, gtools, splines, GeneNet (>= 1.2.13), longitudinal (>= 1.1....