Background: Exercise-induced pulmonary hypertension (EIPH) can be caused not only by pulmonary vas‐ culopathy, but also by a significant increase in left ventricular (LV) filling pressure. This study evaluated the influence of LV diastolic function on EIPH in patients with systemic sclerosis (SSc). Methods: The study included 222 SSc patients (age 58.9 ± 13.1 years, 85% female) and 30 controls ...

Membrane bioenergetics are universal, yet the phospholipid membranes of archaea and bacteria-the deepest branches in the tree of life-are fundamentally different. This deep divergence in membrane chemistry is reflected in other stark differences between the two domains, including ion pumping and DNA replication. We resolve this paradox by considering the energy requirements of the last universa...

INTRODUCTION Pulmonary hypertension (PHT) has been reported to occur in a considerable proportion of patients with end-stage renal disease (ESRD). It is a progressive condition of the pulmonary circulation that poses prognostic importance. In this study, we sought to investigate the prevalence and the predictors of PHT among ESRD patients undergoing renal transplantation. PATIENTS AND METHODS...

OBJECTIVE Pulmonary arterial hypertension (PAH) is a devastating complication of inflammatory rheumatic diseases. The aim of this study was to determine the role of screening for the early diagnosis of pulmonary hypertension (PH) in inflammatory rheumatic diseases. MATERIAL AND METHODS Data of patients with inflammatory rheumatic diseases and PH who had no obvious cause of PH and who were eva...

OBJECTIVE Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are common complications of systemic sclerosis (SSc). Echocardiography evaluates PAH, and chest sonography detects even mild ILC as ultrasound lung comets (ULC), i.e. multiple comet-tails fanning out from the lung surface and originating from subpleural interlobular septa thickened by fibrosis. AIM to assess I...

Abbreviations: ACC/AHA, American College of Cardiology/American Heart Association; AF, atrial fibrillation; ANP, Atrial Natriuretic Peptide; AS, aortic stenosis; BNP, Brain Natriuretic Peptide; EF, ejection fraction; ESC, European Society of Cardiology; LA, left atrium; MR, mitral regurgitation; MS, mitral stenosis; MVA, mitral valve area; NT-Pro-BNP, N terminal-pro brain natriuretic peptide; P...

We describe the isolation and characterisation of novel non-benzoquinone ansamycin metabolites related to geldanamycin from a culture of Streptomyces sp. S6699. The compounds possess potent inhibitory activity in a cell-based assay measuring inhibition of oncostatin M signalling in a reporter cell line utilising a secreted placental alkaline phosphatase (sPAP) readout. In this paper we report t...

for any reduced commutative $f$-ring with identity and bounded inversion, we show that a condition which is obviously necessary for the socle of the ring to coincide with the socle of its bounded part, is actually also sufficient. the condition is that every minimal ideal of the ring consist entirely of bounded elements. it is not too stringent, and is satisfied, for instance, by rings of conti...

BACKGROUND It has recently been shown that commercial air travel triggers hypoxic pulmonary vasoconstriction and modestly increases pulmonary artery pressure in healthy passengers. There is large interindividual variation in hypoxic pulmonary vasoreactivity, and some passengers may be at risk of developing flight-induced pulmonary hypertension, with potentially dangerous consequences. This stud...