introduction: hydrogen sulfide (h2s) plays a key role in the regulation of vascular tone and protection of blood vessels against endothelial dysfunction. since the mechanism of salt impairing h2s-induced vascular relaxation is not fully clear, therefore this study was designed to investigate the role of potassium (k+) channels in the vasodilatory effects of exogenous h2s in rat aortic rings. ma...

Cent Eur J Urol 2013; 66: 195 10.5173/ceju.2013.02.art20 The manuscript entitled “α–blockade, apoptosis and prostate shrinkage: how are they related?” published in this issue reviews the recent literature that links alpha–1 adrenoreceptor antagonists with apoptosis and reduction of prostate size [1]. Alpha–1 adrenoreceptor antagonists have been linked with reducing prostate vascularity in both ...

INTRODUCTION Recent data about radiographic progression during treatment with tumor necrosis factor-alpha (TNF-alpha) blocker agents in patients with ankylosing spondylitis (AS) have prompted an intensive discussion about the link between inflammation/bone destruction and new bone formation and the order of events. Therefore, we analysed parameters of cartilage degradation, neoangiogenesis, and...

The effect of epinephrine on transport of K+, Na+, Cl-, and[Formula: see text] across the rat colon was studied using the Ussing chamber technique. Epinephrine (5 × 10-6 mol/l) induced a biphasic change in short-circuit current ( I sc) in distal and proximal colon: a transient increase followed by a long-lasting decay. The first phase of the I sc response was abolished in Cl--poor solution or a...

We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core an...

Bradycardia, renal failure, Atrioventricular (AV) nodal Blocker Drug Use, Shock, and Hyperkalemia (BRASH) syndrome is a clinical condition frequently seen in emergency services but with low diagnostic awareness. In cases of the syndrome, its cause was determined to be synergistic effect hyperkalemia due failure use AV blocker drugs. The common features patients diagnosed BRASH are moderately el...

provided the original work is properly cited. CC Bronchial blockers are simple alternative methods of facilitating placement of devices for one-lung ventilation. The Coopdech bronchial blocker (Daiken Medical, Osaka, Japan) has been clinically introduced to perform one-lung ventilation with a single-lumen tracheal tube [1]. The distal tip of the Coopdech bronchial blocker has a pre-formed angul...