Penelitian ini bertujuan menganalisis fase spermatogenesis sidat hasil induksi kombinasi hormon 17α-metil testosteron (MT) dan anti dopamin (AD). Tiga perlakuan diatur sebagai berikut: AD 10 µg.kg–1 (A); AM 3 mg.L–1 (AM) larutan fisiologis NaCl 9 kontrol (F). Sidat (200±15 g) dikelompokkan menjadi tiga unit percobaan yang dipelihara dalam bak beton berkapasitas 3.400 liter berisi air sebanyak 2...

TRAIL (TNFSF10/Apo2L) is a member of the tumor necrosis factor (TNF) superfamily of proteins and is expressed in human and rodent testis. Although the functional role of TRAIL in spermatogenesis is not known, TRAIL is recognized to induce apoptosis via binding to its cognate receptors; DR4 (TRAIL-R1/TNFRSF10A) and DR5 (TRAIL-R2/TNFRSF10B). Here, we utilize Trail gene-deficient (Trail-/-) mice t...

Genetic lesions causing human male infertility are manifold. Besides gross chromosomal aneuploidies and rearrangements, microdeletions and single gene defects can interfere with male fertility. Male fertility is not only dependent on genes controlling the male germ line but also on genes of the networks functional for male gonad development and male somatic development, respectively. It is popu...

INTRODUCTION The hormone-dependent events that occur throughout the first wave of spermatogenesis, such as the establishment of the number of Sertoli cells (SCs) and spermatogonial stem cells (SSCs) within the seminiferous cords and the setting up of the blood-testis barrier, are important for adult male fertility. Any changes in the T/DHT ratio can result in male subfertility or even infertili...

Genetic lesions causing human male infertility are manifold. Besides gross chromosomal aneuploidies and rearrangements, microdeletions and single gene defects can interfere with male fertility. Male fertility is not only dependent on genes controlling the male germ line but also on genes of the networks functional for male gonad development and male somatic development, respectively. It is popu...

Drosophila spermatogenesis is an ideal system to study the effects of changes in lipid composition, because spermatid elongation and individualization requires extensive membrane biosynthesis and remodelling. The bulk of transcriptional activity is completed with the entry of cysts into meiotic division, which makes post-meiotic stages of spermatogenesis very sensitive to even a small reduction...

Recent large-scale transcriptional profiling experiments of mammalian spermatogenesis using rodent model systems and different types of microarrays have yielded insight into the expression program of male germ cells. These studies revealed that an astonishingly large number of loci are differentially expressed during spermatogenesis. Among them are several hundred transcripts that appear to be ...

cinnamon has many therapeutic effects, such as its impact the increase of sexual ability. this experiment was conducted to determine the effect of cinnamon extract on spermatogenesis and hormonal axis of pituitary gonad in mice. the animals used in this study are male adult mice (weighing about 30-34 g and 9-10 weeks old). cinnamon was purchased from one of the most valid shops in jahrom and th...

background: olive ( olea europea ), from the oleaceae family, is known as a phytoestrogen plant compound, containing lignans and phenolic compounds. some studies have shown phytoestrogens to have spermatogenesis-decreasing effects. objective: the present study investigated the effects of a hydro-alcoholic extract of olive fruit on reproductive argons in male rats. materials and methods: the hyd...

Mammalian spermatogenesis is a highly regulated multistage process of sperm generation. It is hard to uncover the real function of a testis specific gene in vitro since the in vitro model is not yet mature. With the development of the CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9) system, we can now rapidly generate knockout mouse models of testis sp...