In early mitosis, the END (Emi1/NuMA/Dynein-dynactin) network anchors the anaphase-promoting complex/cyclosome (APC/C) to the mitotic spindle and poles. Spindle anchoring restricts APC/C activity, thereby limiting the destruction of spindle-associated cyclin B and ensuring maintenance of spindle integrity. Emi1 binds directly to hypophosphorylated APC/C, linking the APC/C to the spindle via NuM...

During cell division, a microtubule-based mitotic spindle mediates the faithful segregation of duplicated chromosomes into daughter cells. Proper length control of the metaphase mitotic spindle is critical to this process and is thought to be achieved through a mechanism in which spindle pole separation forces from plus-end-directed motors are balanced by forces from minus-end-directed motors t...

Spindle cell lipoma is a benign, lipomatous tumor arising most frequently in the subcutaneous on back of neck and shoulders males aged third through seventh decade life. However, we encountered case an unusual spindle skin layer dorsum nose. A total two reports have been found nasal regions. To our knowledge, this first report dorsum.

objective: to study the structure and distribution of microtubules in embryos derived from young, old and reconstructed oocytes. materials and methods: embryos obtained from old (50 embryos), young (50 embryos) and reconstructed oocytes (10 embryos) were studied by immunocytochemistry. the microtubule structures of the embryos were studied by using fluroscent microscopy with fitc-pi filter and ...

Spindles are key components of machine tools. An efficient estimation the spindle condition and its prognosis can improve production efficiency quality due to predictive maintenance planning. This paper proposes a method for predicting remaining useful life (RUL) tool bearings using combined calculation experimental approach. The model based on ISO 281 standard uses monitored real loading condi...

With the increase of spindle speed, heat generation becomes crucial problem high-speed motorized spindle. In order to obtain actual thermal behavior a spindle, digital twin system for characteristics is developed in this paper. The mechanism simulate machine tool through mapping and correcting boundary conditions using data acquisition correction models. proposed includes three modules which ar...

During mitosis, chromosome passenger complexes (CPCs) exhibit a well-conserved association with the anaphase spindle and have been implicated in spindle stability. However, their precise effect on the spindle is not clear. In this paper, we show, in budding yeast, that a CPC consisting of CBF3, Bir1, and Sli15, but not Ipl1, is required for normal spindle elongation. CPC mutants slow spindle el...

Spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. Spindle cell neoplasms can affect the oral cavity. In the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. This article aims to review the spindle cell neoplasms of the oral cavity with emphasis on histopathology.