Recent studies have demonstrated that the actin binding protein, ezrin, and the cAMP-sensor, EPAC1, cooperate to induce cell spreading in response to elevations in intracellular cAMP. To investigate the mechanisms underlying these effects we generated a model of EPAC1-dependent cell spreading based on the stable transfection of EPAC1 into HEK293T (HEK293T-EPAC1) cells. We found that direct acti...

For autonomous agents the problem of deciding what to do next becomes increasingly complex when acting in unpredictable and dynamic environments while pursuing multiple and possibly conflicting goals. One of the most relevant behavior-based models that tries to deal with this problem is the behavior network model proposed by Maes. This model proposes a set of behaviors as purposive perception–a...

One att·empt at explaining human inferencing is that of spreading activat,ion, particularly in the st.ructured connectionist paradigm. This has resulted in t.he building of systems with semantically nameable nodes which perform inferencing by examining t.he pat,t.erns of activation spread. In this paper we demonst.rate t.hat simple structured network infert'ncing can be p(>rformed by passing ar...

We previously reported that the disruption of cell spreading by v-Crk was dependent on the activation of the MEK/ERK pathway. Here we demonstrate that the activation of that pathway is sufficient to suppress cell spreading. The MEK/ERK pathway regulates the activity of various proteins including AP-1, which is a transcriptional factor composed of heterodimeric proteins. To examine whether AP-1 ...

Named entities and WordNet words are important in defining the content of a text in which they occur. Named entities have ontological features, namely, their aliases, classes, and identifiers. WordNet words also have ontological features, namely, their synonyms, hypernyms, hyponyms, and senses. Those features of concepts may be hidden from their textual appearance. Besides, there are related co...

The action-based model of dissonance predicts that following decisional commitment, approach-oriented motivational processes occur to assist in translating the decision into effective and unconflicted behavior. Therefore, the modulation of these approach-oriented processes should affect the degree to which individuals change their attitudes to be more consistent with the decisional commitment (...