Tropical sprue is a well documented condition with a special geographical distribution. This paper describes five patients with unexplained malabsorption whose symptoms began during a period of residence in the Middle East or Mediterranean areas.

A viscoplastic deformation model considering material damage is used to predict hot tear formation in a permanent mold magnesium alloy casting. The simulation model calculates the solid deformation and ductile damage. The viscoplastic constitutive theory accounts for temperature dependent properties and includes creep and isotropic hardening. Ductile damage theory is used to find mechanically i...

Celiac disease is the most important cause of intestinal villous atrophy. Seronegative intestinal villous atrophy, including those that are nonresponsive to a gluten-free diet, is a diagnostic challenge. In these cases, before establishing the diagnosis of seronegative celiac disease, alternative etiologies of atrophic enteropathy should be considered. Recently, a new clinical entity responsibl...

Strategies to improve quality of gravity die casting for Sn-Pb alloy are outlined here by modifying the mould's gating system, i.e. mainly down sprue and well. Analysis based on experimental work 27 products delivers a promising result industrial application. Quantitative analysis porosity defect in this was density analysis. The investigation effect design defects worked out through variation ...

background: celiac sprue (gluten sensitive enteropathy) is an autoimmune disease which is hereditary and its pathology mainly bases on immunologic intolerance to gluten. it has a vast variety of signs and symptoms and its clinical features range from a silent disease to a typical gastrointestinal disorder. in this study we reviewed and summarized some other related issues about this disease and...

Loss of response to a gluten-free diet (refractory sprue) and ulcerative jejunitis are complications of celiac disease that may progress to enteropathy-associated T-cell lymphoma (EATL). Both conditions are characterized by the presence of a nonlymphomatous monoclonal T-cell population in the enteropathic mucosa. In EATL, a similar monoclonal population that shows clonal identity with the lymph...

BACKGROUND Celiac sprue (gluten sensitive enteropathy) is an autoimmune disease which is hereditary and its pathology mainly bases on immunologic intolerance to gluten. It has a vast variety of signs and symptoms and its clinical features range from a silent disease to a typical gastrointestinal disorder. In this study we reviewed and summarized some other related issues about this disease and ...

The mechanism for activation of extracellular transglutaminase 2 (TG2) in the small intestine remains a fundamental mystery in our understanding of celiac sprue pathogenesis. Using the T84 human enterocytic cell line, we show that interferon-γ (IFN-γ), the predominant cytokine secreted by gluten-reactive T cells in the celiac intestine, activates extracellular TG2 in a dose-dependent manner. IF...