Styrylquinoline derivatives (SQ) efficiently inhibit the 3'-processing activity of integrase (IN) with IC50 values of between 0.5 and 5 microM. We studied the mechanism of action of these compounds in vitro. First, we used steady-state fluorescence anisotropy to assay the effects of the SQ derivatives on the formation of IN-viral DNA complexes independently of the catalytic process. The IC50 va...

In this work we establish an approach to model miscibility gaps of alloys using statistical physics, lattice dynamics from first-principles calculations. We carefully calculate the entropy include all processes introducing disorder system, i.e., combining electronic, phononic, and configuration entropies. Furthermore present our algorithm for generating Special Quasirandom Structures (SQS). gap...

The Super Chern-Simons mechanics, and quantum mechanics of a particle, on the coset super-manifolds SU(2|1)/U(2) and SU(2|1)/[U(1)× U(1)], is considered. Within a convenient quantization procedure the well known Chern-Simons mechanics on SU(2)/U(1) is reviewed, and then it is shown how the fuzzy supergeometries arise. A brief discussion of the supersphere is also included. ⋆ To appear in Procee...

BACKGROUND Outcomes of studies on mental health screening in primary care are conflicting. A feasible and effective case-finding approach could benefit both GPs and their patients. OBJECTIVES (1) to examine the effect of using a composite screening questionnaire (SQ) on GPs' recognition and provision of care, and (2) to outline useful strategies for case-finding. METHODS 38 GPs in Aarhus Co...

The purpose of this investigation was to compare trunk muscle activity during stability ball and free weight exercises. Nine resistance-trained men participated in one testing session in which squats (SQ) and deadlifts (DL) were completed with loads of approximately 50, 70, 90, and 100% of one-repetition maximum (1RM). Isometric contractions during 3 stability ball exercises (quadruped (QP), pe...

Abstract A Polyakov chiral $$\text {SU(3)}$$ SU(3) quark mean-field (PCQMF) model is applied to study the properties of strange matter (SQM) and star (SQS) in $$\beta $$ β -equilibrium. The effect increasing strength vector interactions on effective constituent mass, particle fractions,...

High ZT value and large Seebeck coefficient have been reported in the nanostructured Fe-doped Si–Ge alloys. In this work, systems was qualitatively reproduced from computed electronic density of states, where a hybrid functional, HSE06, used for an exchange-correlation as well special quasi-random structure (SQS) disordered atomic configuration. Furthermore, by replacing Fe with other transitio...

10.1016/S1674-6384(15)60054-5 Glycyrrhiza uralensis is frequently used in traditional Chinese medicine. This plant contains a large amount of effective constituents, including triterpenoids and flavonoids. Among them, glycyrrhizin is believed to be the marker compound to evaluate the quality of G. uralensis based on Chinese Pharmacopoeia. Many studies showed that glycyrrhizin possesses various ...