Background CMR is the imaging modality of choice to quantify myocardial injury in studies of cardioprotection. Remote ischemic conditioning (RIC), using transient limb ischemia and reperfusion, is a novel therapeutic intervention, which can protect the heart against acute ischemiareperfusion injury (IRI). Whether RIC can reduce myocardial infarct (MI) size, and improve myocardial salvage in ST-...

Several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. This study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-T (hs-TnT) and creatine kinase-MB (CK-MB), in patients with ST-segment elevation myocardial infarction (STEMI) undergoin...

Background The inflammatory response during ST-segment elevation myocardial infarction (STEMI) has been shown to influence the clinical outcome. Moreover, infarct size (IS) and microvascular obstruction (MVO) predict major adverse events in patients with STEMI. The aim of the study was to compare the inflammatory response measured by C-reactive protein (CRP) serum concentration and the number o...

Background The left ventricular global function index (LVGFI) is a novel indicator of cardiac performance. Recently, the LVGFI was linked to left ventricular ejection fraction and infarct characteristics in patients presenting with acute ST-segment elevation myocardial infarction (STEMI). In this study we sought to investigate the association of serially measured high-sensitivity cardiac tropon...

Prompt reperfusion of ischemic myocardium is the major focus of acute treatment of patients with ST-segment elevation myocardial infarction (STEMI). Two reperfusion strategies have been developed: pharmacological and catheter based. Although these two strategies have traditionally been considered distinct and at times competing options, it is likely that care of patients with STEMI will be impr...

New data have re-established the importance of anticoagulation of patients with ST segment elevation myocardial infarction (STEMI), both as an adjuvant to reperfusion therapy or in patients ineligible for reperfusion. Recent randomized trials have found newer agents to be superior to conventional unfractionated heparin. This article summarizes current understanding of the underlying pathophysio...

The contemporary management of patients with acute ST-segment elevation myocardial infarction (STEMI) in the United States has focused upon increasing the timely access to primary percutaneous coronary intervention (PCI) through nationwide quality improvement efforts and the establishment of regional STEMI systems of care across the country (1,2). Nonetheless, because only one-third of the appr...

several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. this study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-t (hs-tnt) and creatine kinase-mb (ck-mb), in patients with st-segment elevation myocardial infarction (stemi) undergoin...

Objective: To investigate the in-hospital mortality rate of STEMI patients treated with IABP according to different TIMI risk scores (TRS). Methods: The clinical data of 897 consecutive ST-segment elevation myocardial infarction (STEMI) patients, without mechanical complications, from July 2005 to July 2013, were retrospectively analysed. The in-hospital outcomes were compared for the 293 patie...

The acute coronary syndromes include unstable angina, ST segment elevation myocardial infarction (STEMI), non-ST segment elevation myocardial infarction (NSTEMI) (1). Worldwide around 7 million people suffer myocardial infarctions per year (White et al., 2008). Around one third of these patients having acute myocardial infarction (AMI) die within the first hour of having symptoms usually due to...