Hematopoiesis in the embryo proceeds in a series of waves, with primitive erythroid-biased waves succeeded by definitive waves, within which the properties of hematopoietic stem cells (multilineage potential, self-renewal, and engraftability) gradually arise. Whereas self-renewal and engraftability have previously been examined in the embryo, multipotency has not been thoroughly addressed, espe...

High-pressure powder x-ray diffraction experiments using synchrotron radiation are performed on the yttrium monochalcogenides YS, YSe, and YTe up to a maximum pressure of 23 GPa. The ambient NaCl structure is stable throughout the pressure range covered. The bulk moduli are determined to be 93, 82, and 67 GPa for YS, YSe, and YTe, respectively. First-principles total energy calculations are car...

If there exists i ∈ Ys which is not among the s-top ranked ones, then we could replace class i in position ji within Ys with class k / ∈ Ys such that pk,t > pi,t obtaining a smaller loss. Next, we show that the optimal ordering within Y ∗ s,t is precisely ruled by the nonicreasing order of pi,t. By the sake of contradiction, assume there are i and k in Y ∗ s,t such that i preceeds k in Y ∗ s,t ...

Supported by Prouty Norris Cotton Cancer Center Funds (YS) and NIH/NINDS R21NS060940 to YS and NR, NIH training grant T32-CA009658-18 YS, and by a Children’s Tumor Foundation Young Investigator Award to MDW. MDW is an Albert J. Ryan fellow. Address correspondence to Yolanda Sanchez Ph.D, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755, United States of America. Phone (603)650-1669 Fax ...

10 Gershenson, S. I., J. Genet., 28, 297-313 (1933). 11TheYsX . YL-chromosome does not permit a decision as to whether YS and yL can conjoin intrachromosomally, even though this chromosome regularly conjoins with itself in Y8X.YL/O spermatocytes (Fig. 3i). Here "Ys" denotes with certainty only the Y8-fertility genes, for the "Ys" element itself (Fig. 3h) is morphologically unlike the short arm ...

We consider a nonlinear polynomial regression model in which we wish to test the null hypothesis of structural stability in the regression parameters against the alternative of a break at an unknown time. We derive the extreme value distribution of a maximum–type test statistic which is asymptotically equivalent to the maximally selected likelihood ratio. AMS 2000 Subject Classification: Primar...

YS-121 [2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid] is the result of target-oriented structural derivatization of pirinixic acid. It is a potent dual PPARα/γ-agonist, as well as a potent dual 5-LO/mPGES-1-inhibitor. Additionally, recent studies showed an anti-inflammatory efficacy in vivo. Because of its interference with many targets, YS-121 is a promising drug can...

Aging is a complex, multifactorial process characterized by the accumulation of deleterious effects, including biochemical adaptations of the extracellular matrix (ECM). The purpose of this study was to investigate the effects of 12 weeks of resistance training (RT) on metalloproteinase 2 (MMP-2) activity in skeletal muscles and, MMP-2 and MMP-9 activity in the blood circulation of young and ol...

OBJECTIVE To evaluate whether a preliminary aspiration (ASP) of the cystic component and/or using spinal needles in complex thyroid nodules (CTN) could improve the adequacy of cytological sampling. METHODS Between January 2004 and December 2006, 386 consecutive patients with CTN were enrolled in this prospective investigation. Ultrasound (US) fine needle aspiration cytology (FNAC) of the soli...