Splenic erythroblasts obtained from BALB/c mice infected with the anemia strain of Friend virus were compared with "matured" cells and adult erythrocytes for their sensitivity to staphylococcal alpha-toxin. Matured cells were obtained by treating erythroblasts in culture with erythropoietin for 48 h. Sensitivity to staphylococcal alpha-toxin, measured both by release of 86Rb and by cell lysis, ...

1. Describe how the approach to the patient who has a staphylococcal infection varies by age, immune status, and clinical presentation. 2. Recognize that the management of staphylococcal infection in the pediatric patient relies on prompt diagnosis and localization of focus. 3. Utilize susceptibility data to plan antimicrobial therapy for staphylococcal infection. 4. Delineate the pharmacokinet...