It has long been thought that the life cycle of Streptomyces bacteria encompasses three developmental stages: vegetative hyphae, aerial hyphae and spores. Here, we show interactions between Streptomyces and fungi trigger a previously unobserved mode of Streptomyces development. We term these Streptomyces cells 'explorers', for their ability to adopt a non-branching vegetative hyphal conformatio...

We have demonstrated that the bldB gene of Streptomyces coelicolor is required for the formation of aerial hyphae and the synthesis of antibiotics. We also found that BldB forms a higher-order complex (most likely a dimer) and that amino acid residues 20 to 78 are important for this interaction. This region is conserved in the BldB family, suggesting that dimer formation may be a common feature...

The development of novel antibacterial drugs needs urgent action due to the global emergence antibiotic resistance. In this challenge, actinobacterial strains from arid ecosystems are proving be promising sources new bioactive metabolites. identified Streptomyces rochei strain CMB47, isolated coal mine Saharan soil, provided an ethyl acetate extract which tested against a series pathogens. It d...

Abstract: Background: Recently, a lot of interest has been focused on the discovery high L-tyrosinaseyielding microorganisms that catalyze production enantiomerically pure L-DOPA, which recognized as conventional treatment for Parkinson's disease. Objectives: The current work primarily isolating novel, promising tyrosinase-producing isolates and performing taxonomical characterization them. Mat...

Streptomyces species has been commonly reported as a cause of mycetoma. Invasive streptomyces infections are rare. We report a case of late onset neonatal septicemia caused by Streptomyces annulatus in a home delivered baby, which was identified based on morphology and biochemical characteristics. Invasive streptomyces infections may be more common than these isolated case reports.

In Streptomyces lividans, the tight temporal regulation of the transient expression of the sblA gene was shown to involve an operator-like sequence located on the sblA transcript. This operator-like structure constitutes a stem-loop structure containing a Shine/Dalgarno-like sequence. Its destruction, by site directed mutagenesis, led to an enhancement of sblA expression. This structure thus pl...

actinomycetes were isolated from marine sediment samples collected from the east coast of chennai, tamil nadu, india. well diffusion and agar plug methods were used for the evaluation of antibiotic production by these isolates against drug resistant methicillin- resistant staphylococcus aureus (mrsa) and vancomycin resistant enterococci (vre). the potential isolate vitbrk2 was mass cultured for...

We sequenced and annotated the complete 7,170,504-bp genome of a novel secondary metabolite-producingStreptomycesstrain,Streptomyces albusSM254, isolated from copper-rich subsurface fluids at ~220-m depth within the Soudan Iron Mine (Soudan, MN, USA).

Expression of genes belonging to the pho regulon in Streptomyces coelicolor is positively regulated (as shown by comparing the wild-type and a DeltaphoP mutant) by binding of the response regulator PhoP to 11-nt direct repeats (DRus). These sequences have been found in over 100 genes of Streptomyces coelicolor; 20 of them were cloned and the binding of PhoP(DBD) to most of their promoters has b...

The draft genome sequences of the three pathogens of potato common scab, Streptomyces scabiei S58, Streptomyces turgidiscabies T45, and Streptomyces acidiscabies a10, isolated in Japan, are presented here. The genome size of each strain is >10 Mb, and the three pathogenic strains share genes located in a pathogenicity island previously described in other pathogenic Streptomyces species.