PURPOSE 5-Hydroxytryptamine-3 receptor antagonists (5-HT(3) antagonists) are effective for preventing acute chemotherapy-induced emesis but the benefits of continuing administration of these agents beyond 24 hours after chemotherapy (delayed emesis) remain unclear. The purpose of this study was to provide estimates of clinical efficacy and drug acquisition cost associated with administering 5-H...

AIMS The Home or Hospital in Heart failure (HHH) study was a European Community-funded, multinational, randomized controlled clinical trial, conducted in the UK, Poland, and Italy, to assess the feasibility of a new system of home telemonitoring (HT). The HT system was used to monitor clinical and physiological parameters, and its effectiveness (compared with usual care) in reducing cardiac eve...

The 5-HT3B subunit was first cloned in 1999, and co-expression with the 5-HT3A subunit results in heteromeric 5-HT₃AB receptors that are functionally distinct from homomeric 5-HT₃A receptors. The affinities of competitive ligands at the two receptor subtypes are usually similar, but those of non-competitive antagonists that bind in the pore often differ. A competitive ligand and allosteric modu...

Depression is a major psychiatric disorder. It affects millions of people worldwide and inflicts tremendous economic burden on societies. The advent of selective serotonin re-uptake inhibitors as antidepressants has been a revolutionary advance in the treatment of depression and related disorders. However, selective serotonin re-uptake inhibitors are also associated with several undesirable pro...

Background: This Retrospective Study was conducted by collecting patient records from the COVID-19 registry of Parul Sevasharm Hospital. The goal this study to investigate risk and mortality patients with Metabolic Syndrome especially during second wave pandemic. Methods: record admitted pandemic (April – June, 2021) were included analyzed for syndrome, Demographic characteristics Clinical Outc...

serotonin (5-ht), a mono-aminergic neurotransmitter is biochemically derived from tryptophan and is mainly found in gastrointestinal tract, platelets and central nervous system of animals. serotonin (5-ht) in coordination with hypothalamus plays an important role in the cns control of appetite, eating behavior, and energy balance and body weight. it has a special role in control of carbohydrate...

BACKGROUND AND PURPOSE Hemorrhagic transformation (HT) is the most critical complication of thrombolytics in clinical trials in acute stroke. The aim of this study was to determine the rates and the predictors of HT in the Multicenter Acute Stroke Trial-Europe (MAST-E) study. METHODS We performed a post hoc analysis of MAST-E data designed to assess the safety and efficacy of streptokinase ad...

The serotonin-1A (5-HT(1A)) receptor is an abundant post-synaptic 5-HT receptor (heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the major somatodendritic autoreceptor that negatively regulates 5-HT neuronal activity. Based on animal models, an integrated model for opposing roles of pre- and post-synaptic 5-HT(1A) receptors in anxiety and depression phenoty...

It is an honor for me to be invited to contribute to this “personal review” of Blood Pressure. A prestigious journal focused on hypertension (HT) management and research, Blood Pressure is nowadays more relevant than ever, as an abundance of evidence has been accumulated which proves that blood pressure (BP) is linearly related to cardiovascular diseases (CVD) complications without a cut-off po...

Introduction and aim: Hemorrhagic transformation (HT) is the most feared complication in acute phase of ischemic stroke. Predicting HT utmost importance clinical practice. In latest years a lot prediction scores have been proposed, but their comparison real life lack. Therefore, aim our study was to provide information about this topic. Materials Methods: We retrospectively calculated THRIVE, S...