AIM A common cause of low back pain is lumbar spinal stenosis (LSS). The Swiss Spinal Stenosis Score (SSS) is a well-known questionnaire that measures the severity of symptoms, physical functioning and patient's satisfaction in lumbar spinal stenosis. This study aimed to translate and validate the SSS in Iran. METHODS A prospective clinical validation study was performed. Forward-backward pro...

Methods We investigated 79 patients with stable angina pectoris who underwent both 64-slice or dual-source CTCA and FFR measurement of discrete coronary stenoses. CTCA and conventional coronary angiography (CCA), and QCT and quantitative coronary angiography (QCA), were performed to determine the severity of a stenosis that was compared with FFR measurements. A significant anatomical or functio...

Aortic Valve Disease, includes a range of disorder severity from mild leaflet thickening without valve obstruction, "aortic sclerosis", to severe calcified aortic stenosis. It is a slowly progressive active process of valve modification similar atherosclerosis for cardiovascular risk factors, lipoprotein deposition, chronic inflammation, and calcification. Systemic signs of inflammation, as wal...

Methods Computation of FFR from CCTA data was performed on 159 vessels in 103 patients undergoing CCTA, invasive coronary angiography, and FFR. Independent core laboratories determined FFRCT and CAD stenosis severity by CCTA. Ischemia was defined by an FFRCT and FFR 0.80, and anatomically obstructive CAD was defined as a CCTA with stenosis 50%. Diagnostic performance of FFRCT and CCTA stenosis ...

OBJECTIVES This study investigated the role of fractional myocardial mass (FMM), a vessel-specific myocardial mass, in the evaluation of physiological severity of stenosis. Using computed tomography angiography, the study investigated fractional myocardial mass, a concept of myocardial mass subtended by specific vessel, which could reduce anatomical-physiological mismatch. BACKGROUND Discorda...

1 ABSTRACT Accurate assessment of the stenosis severity is critical in patients with aortic stenosis (AS). The ambiguities and reduced sensitivities of the current diagnostic parameters can result in sub-optimal clinical decision making. In this preliminary study, we investigate the functional diagnostic parameter CDP (ratio of the transvalvular pressure drop to the proximal dynamic pressure) f...

Mitral valve disease is common. regurgitation the second most frequent indication for surgery in Europe and despite decline of rheumatic fever Western societies, mitral stenosis any aetiology a regular finding all echo departments. is, therefore, one common pathologies encountered by echocardiographers, as both primary echocardiography secondary when investigating other cardiovascular processes...

BACKGROUND Aggressive statin therapy to reduce low-density lipoprotein (LDL) cholesterol in patients with normal LDL-cholesterol levels reduces the incidence of future cardiovascular events and enhances atherosclerotic regression in the common carotid artery. We tried to quantify changes in flow-mediated dilatation (FMD), inflammatory cytokines, and the severity of carotid arterial stenosis, af...

BACKGROUND Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays complex and adverse roles on atherosclerosis. Current study was to investigate whether increased plasma Lp-PLA2 level is independently associated with the severity of coronary artery diseases (CAD). METHODS Totally 781 participants were enrolled and performed coronary angiography (CAG) to figure out the number of coronary arte...

OBJECTIVES The MESA (Multi-Ethnic Study of Atherosclerosis) is a population-based study of 6,814 men and women. We sought to analyze the relationship between the extent of coronary artery calcium (CAC) at baseline and the severity of coronary stenoses in clinically indicated coronary angiography studies during follow-up. BACKGROUND CAC is an established predictor of major cardiovascular event...