We have previously reported that two chemically induced sarcomas of BALB/c mice (MCA-1315 and -1321) contained common transplantation antigens which could be detected by immunization of normal BALB/c mice with irradiated tumor cells of each line. This cross-protection could not be detected in animals surgically cured of these tumor lines and challenged with a high dose of tumor cells, but it wa...

Pancreatic ductal adenocarcinomas induced in the Syrian golden ham ster (SGH) by iV-nitrosobis(2-oxopropyl)amine share many similarities with the human disease, including mutations of the K-/HS oncogene. In vitro carcinogenesis studies with immortal SGH pancreatic duct cells indicate that neoplastic transformation in this system can occur without mutational inactivation ofp53 suppressor gene. I...

INTRODUCTION A paucity of data exists on the incidence, diagnosis and treatment of bleeding in women with inherited factor VII (FVII) deficiency. AIM Here we report results of a comprehensive analysis from two international registries of patients with inherited FVII deficiency, depicting the clinical picture of this disorder in women and describing any gender-related differences. METHODS A ...

A field of 1.013 ster in the ROSAT all-sky survey (RASS), centered on the south galactic pole (SGP), has been searched in a systematic, objective manner for clusters of galaxies. The procedure relied on a correlation of the X-ray positions and properties of ROSAT sources in the field with the distribution of galaxies in the COSMOS digitised data base, which was obtained from scanning the plates...

Mitomycin C is an alkylating agent used in cancer chemotherapy that shows some specificity towards hypoxic cells. The therapeutic effects of this compound are thought to result from its metabolic activation by enzymes such as NADPH:cytochrome P-450 reducÃ-ase.In a previous report we described a Chinese hamster ovary cell line resistant to mitomycin C, which had a decreased NADPH:cytochrome P-45...

The effect(s) of the radioprotector 2-[(aminopropyl)amino]ethanethiol (WR1065) on c/s-diamminedichloroplatinum(ll) (cisDDP)-induced cytotoxicity and mutagenesis at the hypoxanthineguanine phosphoribosyl transferase locus in V79 Chinese ham ster cells was examined. With a standard exposure time of 30 min for both agents, WR1065, at a final working concentration of 4 mw, was added to cells either...

It was shown in 1953 by Engelbreth-Holm and Asboe-Hansen (4) that cortisone, injected intraperitoneally, caused a definite reduction in the de velopment of tumors and an increased latent pe riod in albino mice of strain ST/Eh painted once with 9,10-dimethyl-l,2-benzanthracene (DMBA). Similar results were obtained by Boutwell and Rusch (3) with carcinomas induced by benzpyrene. Sulzberger, Herrm...

Far-UV observations in and near the Hubble Deep Fields demonstrate that the Space Telescope Imaging Spectrograph (STIS) can potentially obtain unique and precise measurements of the diffuse far-ultraviolet background. Although STIS is not the ideal instrument for such measurements, high-resolution images allow Galactic and extragalactic objects to be masked to very faint magnitudes, thus ensuri...

Adopting a simple cosmological model for Gamma Ray Bursts (GRBs), following Mao & Paczyński (1992), we generate number vs. peak flux distributions for a range of values of Ω0 (ratio of the density of the universe to the critical density) and zmax (the redshift at which the faintest GRB in the present sample is located), and compare these distributions to one from BATSE GRBs in the 2B catalog. T...