Using specifically labeled 3-*H-phosphoenolpyruvate, the stereochemistry of CO2 (or HCOs) addition was determined for the reactions catalyzed by P-enolpyruvate carboxylase (from peanuts and Acetobocfer xytinum), P-enolpyruvate carboxykinase (from pigeon liver), and P-enolpyruvate carboxytransphosphorylase (from Propionibacterium shermanii). In all cases the addition occurs from the same side of...

The structures (except stereochemistry) of the main components of the rancinamycin complex were determined with IR, UV, and NMR spectra. Rancinamycin I is a mixture of 5 isomeric components, designated Ia, Ib, Ic, Id and Ie. Rancinamycin II is also a mixture of 5 isomeric compounds, designated rancinamycins IIa-IIe. Differences in the acyl group or in stereochemistry probably account for the is...

In course of our screening for new secondary metabolites from ecological niche specialized, phytopathogenic fungi, the plant pathogen Elsinoё pyri, strain 2203C, was found to produce four novel compounds (1-4), which were named elsinopirins A-D, in addition to the known metabolite elsinochrome A (5). After isolation by preparative high-performance liquid chromatography (HPLC), their structures,...

Ossamycin is a cytotoxic agent of undetermined structure that was originally isolated in 1965 from culture broths of Streptomyces hygroscopicus var. ossamyceticus. Its overall structure and relative stereochemistry have now been determined by single crystal X-ray diffraction studies. Absolute stereochemistry was established according to the previously determined configuration of its aminosaccha...

Four synthetic strategies were evaluated towards the preparation of (-)-(3R,4R)-1-benzyl-4-(benzylamino)piperidin-3-ol (1), which was constructed with control over the relative and absolute stereochemistry of the 4,3-amino alcohol moiety. The first strategy employed a novel Rh(I) catalyzed asymmetric hydrogenation, while two other strategies exploited the existing stereochemistry in 2-deoxy-D-r...

The enantioselective synthesis of (-)-dysiherbaine (1) has been established with efficiency via a unique synthetic strategy involving the desymmetrization of 2-substituted glycerol to install a quaternary chiral carbon, which induces further stereochemistry in the bicyclic perhydrofuropyran through mercuriocyclization and epoxidation.

The late Edgar Heilbronner, one of the great physical and organic chemists of the 20th century, had a particularly effective lecture. He started it as follows: “You know pretty much everything I am going to say. So let us begin with the questions.” And up on the screen flashed the first question. The lecture continued in the same vein; Heilbronner’s carefully structured answers to just the righ...

The constitution and relative configuration at the stereogenic centres and stereochemistry of the C-C double bond formed during Pd(II)-catalysed domino reaction was established by X-ray analysis of the title compound, C(10)H(14)O(4). The asymmetric unit contains two mol-ecules.

AnalogExplorer is a computational methodology for the extraction and organization of series of structural analogs from compound data sets and their graphical analysis. The method is suitable for the analysis of large analog series originating from lead optimization programs. Herein we report AnalogExplorer2 designed to explicitly take stereochemical information during graphical analysis into ac...

In the crystal structure of the title compound, C(26)H(18)O(3), mol-ecules with stereochemistry (1R,2S,R), are connected by O-H⋯O hydrogen bonds, forming chains.