background: although giant cell tumor (gct) is considered to be a primary benign bone tumor, its aggressive behavior makes its diagnosis and treatment, difficult and challenging. this is especially true in distal radius where gct appears to be more aggressive and difficult to control locally. we report our clinical outcome of en-block resection and reconstruction with non-vascularized fibular a...

objective(s): the oct4b1, as one of oct4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. the present study was designed to determine the effects of oct4b1 silencing on expressional profile of hsp40 gene family expression in three different human tumor cell lines. materials and met...

Desmoplastic small round cell tumor is a rare malignant tumor that occurs primarily in young males. Here, a case of small round cell tumor in an adult male successfully treated with a curative concurrent chemoradiotherapy is presented. A 58-year-old man had an intrapelvic tumor. Surgical resection was attempted, but the tumor was unresectable. Needle biopsy was performed and the diagno...

Steroid treatment for suspected giant cell arteritis brought no improvement in vision or headache severity.

cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. cancer vaccines induce pe...

A sulfated polysaccharide-peptidoglycan complex, DS-4152, isolated from the culture supernatant of an Arthrobacter species inhibited angiogenesis and tumor growth and enhanced the antiangiogenic activity of 11 steroid hormones by 2 to 100 times. In the presence of cortisone acetate or tetrahydro S, DS-4152 suppressed chick chorioallantoic membrane angiogenesis and murine tumor M5076 cell-induce...

This study aimed to investigate the activities of novel 20(R)-3,20-dihydroxy-19-norpregn-1,3,5(10)-trienes (kuz7 and kuz8b) natural 13β- epimeric 13α-series against triple-negative MDA-MB-231 breast cancer cells. High antiproliferative activity synthesized compounds kuz8b kuz7 cells was revealed. The steroid 13β-configuration more active than 13α-steroid kuz8b. Cell cycle analysis revealed comm...

Steroid biosynthesis was studied in a spontaneous mouse interstitial cell tumor grown as a transplant in isologous male recipients. In timed incubations the tu mor tissue rapidly transformed dehydroepiandrosterone to androstenedione. The formation of testosterone, 11/îhydroxyandrostenedione, and 11/3-hydroxytestosterone proceeded at a slower rate. A conversion product with Chromatographie char...

Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...