Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation-induced transformations in MSC cellular and nuclear biophysical properties and queried their role in mechanosensation. Our data show that nuclei in differentiated bovine and human MSCs stiffen and become resistant to deformation. This attenuated nuclear deformatio...

Abstract In this paper, a variable-fidelity constrained lower confidence bound (VF-CLCB) criterion is presented for computationally expensive optimization problems (COPs) with two levels of fidelity. VF-CLCB, the hierarchical Kriging model adopted to objective and inequality constraints. Two infill sampling functions are developed based on constraints, respectively, an adaptive selection strate...

Stiffened plates are employed in various engineering structures including aerospace, civil, naval, etc. These may be subjected to harmonic loads. Therefore, it is essential understand the response of a cracked stiffened structure. This study presents effects crack location on free vibration and plates. For this purpose, horizontal vertical cracks modelled throughout fixed from two-side The anal...

Initial results of an investigation towards finding an efficient non-cylindrical fuselage configuration for a conceptual blended-wing-body flight vehicle were presented. A simplified 2-D beam column analysis and optimization was performed first. Then a set of detailed finite element models of deep sandwich panel and ribbed shell construction concepts were analyzed and optimized. Generally these...

Currently, lattice composite structures have many applications in aerospace industries. The present research analyzed the effect of an external skin consisting of a lattice’s cylindrical shell on the buckling strength of composite materials, both numerically and experimentally. Two classes of specimens, with and without external skins, were fabricated using the filament winding process. To find...

We study an old mathematical model, developed before the computer era, for analyzing the strength of a stiffened shell roof. The specific problem considered is a textbook example presented in K. Girkmann: Flächentragwerke, 3rd edition, 1954. Here the roof consists of a spherical dome and a stiffening ring of rectangular cross section attached to the edge of the dome. The problem is to compute t...

Deployable structures are a common spacecraft configuration feature. Deployables are used to configure spacecraft inertia properties, provide expanded antenna aperture and solar array area, or to provide separation between spacecraft components. Lightsat design would be especially enhanced by small size lightweight deployable structures. A review of the state of the art of deployable structures...