Abstract Background and Aims Severe primary hyperoxaluria type 1 (PH1) with rapid onset nephrocalcinosis renal function loss in early infancy required so far combined liver kidney transplant. RNA interfering drugs are the new challenge for these children. Here we present first case of a newborn affected by PH1 treated RNA-interfering Lumasiran 6 hours after birth. Method Diagnosis (homozygous m...

introduction: the symptoms of infections caused by toxoplasma gondii range from asymptomatic or mild to severe infection in pregnant women, which results in severe congenital infection, abortion or fetal still birth. the aim of this study was to assess the risk factors and seroepidemiology of toxoplasmosis in pregnant women in their first trimester in bandar abbas. methods: this cross-sectional...

OBJECTIVES To describe the efficacy, safety, and exposure-response relationship of canakinumab in a subgroup of patients with systemic juvenile idiopathic arthritis (SJIA) aged ≥16 years, representative of adult-onset Still's disease (AOSD) patients, and to compare this subgroup with those of children and young adolescents with SJIA by pooling clinical data collected during the development prog...

Introduction The greater part of the literature on the occurrence of amyloidosis in rheumatoid arthritis and in Still's disease comes from the Western Hemisphere. Since the recent publication in this country of such a case by Yeoman and Wilson (1947) the interest of rheumatologists on this side of the Atlantic has been awakened and a watch has been kept for further cases. Over 200 cases of rheu...

Parents of 135 children with juvenile rheumatoid arthritis (JRA) completed a mailed questionnaire about problems at school. Writing was the most frequently reported difficulty, with hand involvement causing more problems than decreased mobility. Compared to children with pauciarticular JRA, those with polyarticular or systemic JRA were significantly more likely to miss school, experience proble...

The events leading to preterm birth are still not completely understood. A quantitative systematic review was performed to estimate the effects of periodontal care during pregnancy on preventing preterm birth and low birth weight. The meta-analysis included randomized trials with pregnant women with a diagnosis of periodontal disease before 20 weeks of gestation. Relative risk (RR) with 95% con...

background: about 21 millions premature and low birth weight (lbw) infants are born in the world every year where the majority of them are in the middle east countries. the literatures have shown that lbw infants and premature infants have a smaller chance to survive than the normal ones. this research carried out to determine the situation of catch up growth of lbw infants in comparison with n...

OBJECTIVE To assess performance of the WHO revised verbal autopsy tool for ascertaining the causes of still birth in comparison with reference standard cause of death ascertained by standardized clinical and supportive data. METHODS All stillbirths at a tertiary hospital in Karachi, Pakistan were prospectively recruited into study from August 2006- February 2008. The reference standard cause ...