Gastric diseases cause considerable worldwide burden. However, the stomach is still poorly understood in terms of the molecular-cellular processes that govern its development and homeostasis. In particular, the complex relationship between the differentiated cell types located within the stomach and the stem and progenitor cells that give rise to them is significantly understudied relative to o...

Currently, proton pump inhibitors (PPIs), H2-histamine receptor blockers (H2-blockers), antacids, and anticholinergics are used to treat acid-dependent diseases of the gastrointestinal tract. PPIs considered most effective drugs for treatment However, in real clinical practice, interest remains use antacids diseases. This is due fact that not only adsorb hydrochloric acid gastric lumen (by buff...

Gastroparesis (GP) is associated with depletion of interstitial cells of Cajal (ICCs) and enteric neurons, which leads to pyloric dysfunction followed by severe nausea, vomiting and delayed gastric emptying. Regenerating these fundamental structures with mesenchymal stem cell (MSC) therapy would be helpful to restore gastric function in GP. MSCs have been successfully used in animal models of o...

UNLABELLED This study was designed to investigate the feasibility and effectiveness of a modified protocol for (18)F-FDG PET that was proposed to improve the identification of primary gastric malignancies. METHODS In the modified protocol, patients were asked to drink 300-500 mL of cow milk to distend the stomach immediately before PET scans instead of fasting all along. For investigation of ...

The main factors causing digestive disorders are food that is not good in terms of hygiene and health, nutritional balance, improper diet, infection, abnormalities the organs so they will contract several diseases such as appendicitis, ulcers, stomach hepatitis. , diarrhea constipation. Early treatment needed before consulting specifically with a disease specialist severe. In this case, it nece...

background & aim: homalium letestui pellegr (flacourtiaceae) used traditionally by the ibibios of southern nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  experimental: the effects of ethanol stem extract of h. letestui (200 – 600 mg/kg) and fractions (aqueous and dichloromethane, 400 mg/kg) on experimentally induced ulcer wer...

homalium letestui pellegr (flacourtiaceae) is used traditionally by the ibibios of southern nigeria to treat stomach ulcer, malaria and other inflammatory diseases and yorubas of western nigeria as an antidote. the hepatoprotective effect of the stem extract (200-600 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, tot...

An overview of Helicobacter pylori infection The discovery of the bacterium Helicobacter pylori (H. pylori), resident in the human stomach, as the causal agent of chronic disease including chronic gastritis, peptic ulcer diseases, and gastric cancer, was revolutionary in gastroenterology. Whereas the mouth and the colon were both known to host a large number of microorganisms, collectively refe...

A 22-year-old male presented with recurrent upper gastrointestinal bleeding along with pain in the abdomen. An upper gastrointestinal endoscopy revealed Menetrier’s disease affecting the body of the stomach, which was confirmed histopathologically [Figure 1]. There was hyperplasia of foveolar cells with elongation of the crypts, decrease in the number of gastric glands and mild lymphocytic infi...

Ghrelin is a peptide hormone, which has been isolated from the stomach. It is localized mostly in endocrine cells in the oxyntic mucosa of the stomach. Ghrelin receptors are expressed equally in all parts of the gastrointestinal tract, with a similar level of expression in the mucosal and muscle layers. This peptide hormone has several functions, the most widely known is its growth hormone (GH)...