Cancer in the central nervous system can arise from a primary brain tumor and metastasize to the brain or to the leptomeninges, leading to leptomeningeal metastasis (LM). LM also is called leptomeningeal carcinomatosis and carcinomatous meningitis. When LM occurs, signs and symptoms include headache, nausea, vomiting, lumbar back pain, and stiff or painful neck; LM also may lead to mental distu...

Listeria monocytogenes (Lm) evade microbicidal defences inside macrophages by secreting a pore-forming cytolysin listeriolysin O (LLO), which allows Lm to escape vacuoles. LLO also inhibits Lm vacuole fusion with lysosomes, which indicates LLO alters vacuole chemistry prior to release of Lm into cytoplasm. Using fluorescent probes to measure membrane permeability, calcium and pH, we identified ...

This study aimed to generate equations for the indirect determination of lactate minimum (LM) intensity from short-distance maximal performances in 10- to 17-year-old swimmers. Seventy-one male (n = 41) and female (n = 30) competitive swimmers were divided into subgroups: one to generate predictive equations for LM (~70% of the sample), and the second to cross-validate the proposed equations (~...

Kinetic energy (KE) spectra derived from global high-resolution atmospheric simulations from the Model for PredictionAcross Scales (MPAS) are presented. The simulations are produced using quasi-uniform global Voronoi horizontal meshes with 3-, 7.5-, and 15-km mean cell spacings. KE spectra from the MPAS simulations compare well with observations and other simulations in the literature and posse...

Text corpus size is an important issue when building a language model (LM). This is a particularly important issue for languages where little data is available. This paper introduces an LM adaptation technique to improve an LM built using a small amount of task dependent text with the help of a machine-translated text corpus. Icelandic word error rate experiments were performed using data, mach...

We present CCMC (Conditional CSL Model Checker), a model checker for continuous-time Markov chains (CTMCs) with respect to properties specified in continuous-time stochastic logic (CSL). Existing CTMC model checkers such as PRISM or MRMC handle only binary CSL until path formulas. CCMC is the first tool that supports algorithms for analyzing multiple until path formulas. Moreover, CCMC supports...

We consider deployment of the particle filter on modern massively parallel hardware architectures, such as Graphics Processing Units (GPUs), with a focus on the resampling stage. While standard multinomial and stratified resamplers require a sum of importance weights computed collectively between threads, a Metropolis resampler favourably requires only pair-wise ratios between weights, computed...