Background. Currently, diabetes mellitus is the most common of all endocrine diseases with increasing tendency. The purpose our research was to study dynamics serum levels proinflammatory cytokine-IL-1β in streptozotocin-induced diabetes. Materials and methods. experiments were performed on 88 white male Wistar rats weighing 170-210 g. Animals divided into three groups: 1 - intact; 2 control; 3...

The cholecystokinin B receptor (CCK(B)R) is localized on pancreatic endocrine somatostatin delta-cells. Pancreatic somatostatin content was increased in diabetic rats. The mechanisms involved in this phenomenon are unknown, and we believe insulin is involved. In this study, four groups of rats were used: controls, streptozotocin-induced diabetic, streptozotocin-induced diabetic with insulin, an...

Diabetes mellitus has been a metabolic disorder characterized by interferences in the breakdown of carbohydrate, lipid, and protein as result insulin deficiency. Great efforts are ongoing understanding management diabetes, disease related complication. In this work, an attempt was made to study hematological hypoglycemic effects Annona muricata ripe fruits pulp Streptozotocin (STZ)-induced diab...

There is evidence that inducible nitric oxide synthase (iNOS) is activated at the acute phase of diabetes. We examined if selective inhibition of iNOS by 1400W (N-3-aminomethyl-benzyl-acetamidine) increases vascular response to noradrenaline in rats with streptozotocin (60 mg/kg i.v.)-induced diabetes for a duration of 3 weeks. The effects of noradrenaline on mean arterial pressure (MAP; 6, 16,...

Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β-cell destruction and widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-induced insulin deficiency hyperglycemia mice rats. Also described creating animal models 2 using STZ. These animals employed assessing the pathological consequences sc...

Diabetic erectile dysfunction is associated with penile dorsal nerve bundle neuropathy in the corpus cavernosum and the mechanism is not well understood. We investigated the neuropathy changes in the corpus cavernosum of rats with streptozotocin-induced diabetes and the effects of Icariside II (ICA II) on improving neuropathy. Thirty-six 8-week-old Sprague-Dawley rats were randomly distributed ...

Whether diabetes enhances or diminishes the host response to bacteria has been controversial. To determine how diabetes alters the inflammatory response, we inoculated P. gingivalis into the scalps of mice rendered diabetic with multiple low-dose streptozotocin treatment. On day 1, a moderate to severe inflammatory infiltrate was noted in both the diabetic and normoglycemic mice. After 3 days, ...

BACKGROUND AND PURPOSE Stroke and heart disease are the most serious complications of diabetes accounting for >65% of mortality among diabetics. Although intensive insulin therapy has significantly improved the prognosis of diabetes and its complications, it is associated with an elevated risk of recurrent hypoglycemia (RH). We tested the hypothesis that RH exacerbates cerebral ischemic damage ...