BACKGROUND Niemann-Pick type C disease (NPC) is a neurovisceral lipid storage disorder mainly characterized by unesterified cholesterol accumulation in lysosomal/late endosomal compartments, although there is also an important storage for several other kind of lipids. The main tissues affected by the disease are the liver and the cerebellum. Oxidative stress has been described in various NPC ce...

OBJECTIVE Routine delays in the diagnosis of primary adrenal insufficiency (PAI) are well known and conceivably attributable to the absence of cues, other than anti-adrenal autoantibodies, to pursue subclinical PAI. Subclinical PAI is latent unless the afflicted patient encounters stress such as an acute illness, surgery, psychosocial burden, etc. It remains to be demonstrated whether a history...

Oxidative stress defines an imbalance between formation of reactive oxygen species (ROS) and antioxidative defence mechanisms. In view of the profound biological effects of ROS, in recent years numerous clinical and experimental studies focused on detection of signs of oxidative stress in renal patients. There is good evidence indicating that uraemia in general is associated with enhanced oxida...

The immune system of 90-day old piglets SM-1 Novosibirsk breed depends on sex and stress-reactivity. Stress-reactivity was measured using halothane test. immunologic testing performed 30 days after weaning. Our results show that overall piglet demonstrated high proliferative activity T- B- immunocompetent cells with active formation mature T-and B-lymphocytes did not signs immunosuppression. Co...

  The aim of this study was to determine the prevalence and clinical characteristics associated with stress Hyperglycemia among patients attending to the neonatal and pediatric Emergency wards. Patients who require d blood sampling for evaluated of an acute illness from August 1995 to July 1996 to the Namazi hospital of Shiraz medical university were enrolled prospectively for Hyperglycemia ( ...

Brain aging is a degenerative process manifest by impairment of cognitive function; although not all pets are affected at the same level, once cognitive decline begins it is generally a progressive disorder. Diagnosis of cognitive dysfunction syndrome (CDS) is based on recognition of behavioral signs and exclusion of other medical causes that might mimic CDS or complicate its diagnosis. Drugs, ...