BACKGROUND White matter lesions (WML) and brain atrophy are important biomarkers in stroke and dementia. Stroke lesions, either acute or old, symptomatic or silent, are common in older people. Such stroke lesions can have similar signals to WML and cerebrospinal fluid (CSF) on magnetic resonance (MR) images, and may be classified accidentally as WML or CSF by MR image processing algorithms, dis...

PURPOSE The present study compared the effects of aerobic endurance training at different intensities and with different methods matched for total work and frequency. Responses in maximal oxygen uptake (VO2max), stroke volume of the heart (SV), blood volume, lactate threshold (LT), and running economy (CR) were examined. METHODS Forty healthy, nonsmoking, moderately trained male subjects were...

The outflow of blood from the chest during the phases of the cardiac cycle is found to be nearly equaled by a phasic inflow. The net volume change exerts very small pressure changes in the intrathoracic (intrapulmonary) air. This is not due to the distensibility of the chest wall because when allowance is made for this factor and the intrathoracic blood volume change is calculated, it is found ...

Fat-free mass (FFM) (primarily skeletal muscle mass) is related to maximal aerobic capacity among healthy humans across the adult age range. The basis for this physiological association is assumed to be a direct relation between skeletal muscle mass and its capacity to consume oxygen. We tested the alternative hypothesis that FFM exerts its influence on maximal aerobic capacity in part via an a...

To determine the effect of respiration on systolic and diastolic time intervals, simultaneous phonocardiograms, carotid pulse tracings, M mode echocardiograms, and respiratory curve tracings were measured in 25 healthy subjects. The positioning of each cardiac cycle in relation to the phase of respiration was assessed and the dependency of heart rate and cardiac time intervals on respiration wa...

Accurate identification of fluid responsiveness has become an important issue in critically ill patients. Pulse pressure and stroke volume variation have been shown to be reliable predictors of fluid responsiveness. Apart from these two valuable techniques, echo-Doppler offers an interesting alternative for estimating the adequacy of filling. Acoustic quantification is a high-tech tool for deli...

We propose that cardiovascular drift, characterized by a progressive decline in stroke volume after 10-20 min of exercise, is primarily due to increased heart rate rather tahn a progressive increase in cutaneous blood flow as body temperature rises.

Social disparities in health persist into old age, and differences in psychophysiological responsivity may contribute to this pattern. We assessed whether higher socioeconomic status (SES) is associated with attenuated cardiovascular and neuroendocrine responses elicited by cognitive tasks in old age. We tested 132 community-dwelling men and women aged 65-80 years, divided on the basis of educa...

BACKGROUND AND PURPOSE The volume of ischemic stroke on CT scans has been studied in a standardized fashion in acute stroke therapy trials with median volumes between 10.5 to 55 cm(3). The volume of first-ever ischemic stroke in the population is not known. METHODS The first phase of the population-based Greater Cincinnati/Northern Kentucky Stroke Study identified all ischemic strokes occurri...