Correspondence to: Anette Duensing, MD, University of Pittsburgh Cancer Institute Hillman Cancer Center, Research Pavilion, Suite 1.8 5117 Centre Avenue, Pittsburgh, PA 15213 Tel: +1-412-623-5870, Fax: +1-412-623-7715, e-mail: [email protected] Received: April 24, 2010, Accepted: April 27, 2010, Published: on line May 1, 2010 Copyright: C 2010 Duensing et al. This is an open-access article dist...

AIMS AND BACKGROUND In patients with localized gastrointestinal stromal tumors, surgery remains the elective treatment. Nowadays, imatinib therapy has been standardized in advanced gastrointestinal stromal tumors, showing continuous improvements in progression-free and overall survival. A combination of imatinib therapy and surgery may also be effective in a subset of patients with metastatic o...

A population pharmacokinetic study of imatinib in patients with gastrointestinal stromal tumor by Eechoute and colleagues has shown a significant increase in drug clearance over the first 3 months of treatment, resulting in a 30% decrease in drug exposure. This finding clearly shows the possibility of pharmacokinetic resistance in this disease.

In 3 experiments the authors used a new contextual bias paradigm to explore how quickly information is extracted from a scene to activate gist, whether color contributes to this activation, and how color contributes, if it does. Participants were shown a brief presentation of a scene followed by the name of a target object. The target object could be consistent or inconsistent with scene gist b...

The neural correlates of gist and verbatim encoding of episodes sharing semantically related components were investigated. At study, participants were presented with lists of word pairs formed by pairing one of two associated words with different associates of an unstudied theme word. At test, participants discriminated Old pairs from rearranged pairs generated by re-pairing study pairs belongi...

Viewers can recognize the gist of a scene (i.e., its holistic semantic representation, such as its category) in less time than a single fixation, and backward masking has traditionally been employed as a means to determine that time course. The masks used in those paradigms are often characterized by either specific amplitude spectra only, or amplitude and phase spectra-defined structural prope...