Studies of human follitropin (hFSH) structure-activity relationships from the author' s laboratory are reviewed. These include mutagenesis studies that complemented the determination of the three dimensIonal structure of hFSH. Despite a large extracellular domain of the FSH receptor and the complexity and size of both the receptor and the hFSH molecule, only a handful of hFSH amino acids are re...

This paper presents the results of assays for antihemorrhagic activity carried out on an array of naphthoquinones and related compounds synthesized as described in a series of previous papers. Some of the compounds were prepared as synthetic models of the structural types postulat.ed (1) for vitamins K1 and Kz (l-5); others were synthesized subsequent to the establishment of the structure of vi...