Abstract INTRODUCTION Many groups have reported lymphatic and glymphatic structures in animal human brains, but tracer injection into the brain to demonstrate real-time drainage mapping has not been reported. Technetium (99mTc) tilmanocept is a radiopharmaceutical agent that binds CD206 maps draining lymph nodes. We hypothesized peritumoral 99mTc-tilmanocept parenchyma would map cervical Here w...

treatment of spinal cord injury by exogenous cells has brought both successful and unsuccessful results. olfactory ensheathing cells and schwann cells have been widely used for transplantation purposes. in this study, we investigated the effects of these cells on contused spinal cord by introducing cells into subarachnoid space. fifty thousand schwann cells or olfactory ensheathing cells or a m...

We examined the cerebrospinal fluid (CF) taken on admission from 60 patients with infections caused by Neisseria meningitidis for presence of TNF-alpha, IL-1, and IL-6. TNF-alpha was detected in CF in 55 and 19% (p = 0.03), IL-1 in 50 and 15% (p = 0.05), and IL-6 in 98 and 100% of patients with meningitis and septic shock/bacteremia, respectively. The median IL-6 concentration in CF in patients...

Most of Tarlov or perineurial cysts remain asymptomatic throughout the patient's life. The pathogenesis is still unclear. Hemorrhage has been suggested as one of the possible causes and trauma with resultant hemorrhage into subarachnoid space has been suggested as an origin of these cysts. However, Tarlov cysts related to spontaneous subarachnoid hemorrhage has not been reported. The authors re...

Aims: To describe the anatomy and the arrangement of the arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve and to consider their possible clinical relevance for cerebrospinal fluid dynamics and fluid pressure in the subarachnoid space of the human optic nerve. Methods: Postmortem study with a total of 12 optic nerves harvested from nine subjects without...

Continuous infusion of local anaesthetic for epidural analgesia in obstetrics was first described in 1963. t However, this method of providing pain relief in labour did not become popular, probably because of the limitation of the mechanical pumps available at that time and also the tachyphylaxis associated with the use of lidocaine or mepivacaine. 2 Recently, continuous infusions have been des...

In a previous publication we described an experimental form of pneumococcal meningitis in dogs, which was produced by introduction of type III pneumococci into the subarachnoid space through a small midline burr hole placed equidistant between the coronal and occipital sutures (1). The infection produced in this manner involved the entire neuraxis and, with the exception of marked changes in th...

The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral capillaries, i.e. the blood-brain barrier, was studied in normotensive Wistar and spontaneously hypertensive Wistar rats with experimental subarachnoid hemorrhage. The blood-brain barrier permeability to albumin was assessed quantitatively by spectrophotometric determination of Evans blue extravasati...

AIMS To describe the anatomy and the arrangement of the arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve and to consider their possible clinical relevance for cerebrospinal fluid dynamics and fluid pressure in the subarachnoid space of the human optic nerve. METHODS Postmortem study with a total of 12 optic nerves harvested from nine subjects without...

BACKGROUND There is experimental evidence that dexmedetomidine has neuroprotective effects. So, it could be expected that its intrathecal or epidural administration presents no harm. However, whether dexmedetomidine is neurotoxic to the spinal cord remains to be fully elucidated. OBJECTIVE To evaluate the effect of preservative-free dexmedetomidine administered as a subarachnoid single inject...