BACKGROUND Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in sarcoidosis, but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in sarcoidosis. Therefore, the aim of this study is to analyze proportions, phenotype, survival,...

OBJECTIVES Sarcoidosis is a multisystem disease characterised by the formation of granulomas within various organs, mainly the lungs. Several studies from different countries have been undertaken to investigate sarcoidosis with extrapulmonary involvement except from China. The objective of this study is to investigate a comparative clinical analysis in patients with pulmonary sarcoidosis with a...

Sarcoidosis is by definition a disease of "unknown causes," but recent epidemiologic advances suggest that the long-standing definition of sarcoidosis may soon need to be amended. The recently completed ACCESS (A Case-Control Etiologic Study of Sarcoidosis) study was not able to definitively identify the "cause" of sarcoidosis, but yielded important findings regarding familial and environmental...

Sarcoidosis is a granulomatous inflammatory disease, diagnosed through tissue biopsy of involved organs in the absence of other causes such as tuberculosis (TB). No specific serologic test is available to diagnose and differentiate sarcoidosis from TB. Using a high throughput method, we developed a T7 phage display cDNA library derived from mRNA isolated from bronchoalveolar lavage (BAL) cells ...

thirty patients with bilateral lymph node enlargement with or without parenchymal infiltrates on the chest x- ray suspected to have sarcoidosis were studied between june 1980 and december 1989 in our institution. eleven of these patients who were free of parenchymal infiltrates did not have a biopsy performed and the diagnosis of sarcoidosis was made based on self-limited regression and clearin...

Background Löfgren syndrome (LS) is the acute form of sarcoidosis, characterized by erythema nodosum (EN), joints involvement, fever and intrathoracic lymphadenopathy. LS clinical polymorphism leads to diagnostic errors. Objectives To study clinical, laboratory radiological features early stages sarcoidosis in a cohort patients referred rheumatology center. Methods The included 135 (107 females...

Cardiac sarcoidosis is a rare complication of pulmonary sarcoidosis, causing granulomatous inflammation the myocardium, ultimately resulting in infiltrative cardiomyopathy. Through fibrotic inflammation, cardiac predisposes patients to multiple complications, such as conduction abnormalities, ventricular arrhythmias, heart failure, and sudden death. Due adverse prognosis abnormalities these pat...

BACKGROUND Sarcoidosis is a systemic granulomatous disease of unknown cause that affects the lungs in over 90% of cases. Breath analysis by electronic nose technology provides exhaled molecular profiles that have potential in the diagnosis of several respiratory diseases. OBJECTIVES We hypothesized that exhaled molecular profiling may distinguish well-characterized patients with sarcoidosis f...