BACKGROUND The optimal dose of grass pollen tablets for sublingual immunotherapy (SLIT) in allergic rhinoconjunctivitis patients was previously established in a multinational, randomized, double-blind, placebo-controlled study in 628 adults. Patients were randomized to receive once-daily 5-grass pollen sublingual tablets of 100 IR (index of reactivity), 300 IR or 500 IR, or placebo starting 4 m...

BACKGROUND Various studies have shown the clinical efficacy of sublingual immunotherapy in grass pollen-induced rhinoconjunctivitis. However, even short-term treatment with grass extracts might cause sensitizations to formerly unrecognized antigens. OBJECTIVE To determine whether the antibody profiles are changing in patients receiving a defined grass pollen extract prior to and during the gr...

BACKGROUND Immunotherapy with the SQ-standardized grass tablet Grazax is efficacious and well-tolerated in adult patients with rhinoconjunctivitis. Allergic asthma and rhinoconjunctivitis are closely linked, and a strategy combining treatment of the upper and lower airways is recommended. OBJECTIVE To investigate the efficacy of treatment with the grass tablet on grass pollen-induced rhinocon...

Background The aim of this non-interventional study was to document the impact of a sublingual allergen immunotherapy (AIT) with Oralair 5-grass pollen tablets (Stallergenes, France) on symptom severity, use of symptomatic medication and tolerability in patients with grass pollen-induced allergic rhinoconjunctivitis (RC) over 2 years of routine medical practice treatment. This poster focuses on...

Experience shows that it is not economically feasible to for mally specify all parts of a system in an industrial application Either one already has a number of existing components which are trusted and therefore desirable for reuse or components are so simple that there is no gain in formally specifying their behavior In both cases it may be felt that it is not worth spending time on developin...

To the Editor The authors of the article, “Decision-Making Analysis for Allergen Immunotherapy versus Nasal Steroids in the Treatment of Nasal Steroid-Responsive Allergic Rhinitis,” must be commended, because they introduce an original approach to assess the costeffectiveness of subcutaneous immunotherapy (SCIT).1 It is a pity that they did not take into account also sublingual immunotherapy (S...

Since Barger and Dale (1910) described the chemical structure and sympathomimetic action of adrenaline-like amines, adrenaline and adrenergic drugs have been extensively used for the treatment of asthma. Adrenaline itself is active only when it is given parenterally or by inhalation, whereas the more recently introduced isoprenaline is more stable and can be given by inhalation or as a sublingu...