The striatum of the mammalian forebrain can be divided into 2 compartments, the patches and the matrix. We have investigated embryonic events involved in the formation of these compartments in rats. Early in development, dopamine fibers from the substantia nigra selectively innervate the patches. In the perinatal striatum, we observed a close match between the distributions of striatal cell bod...

This paper provides a critical review of the numerous and various biological functions so far attributed to neuromelanin and an attempt to provide a unified theory based on the peculiar physical and chemical properties of the black particle (the neuromelanin cage). It is stressed that neuromelanin is not homogeneous, as is commonly accepted, but is made up of different substrate specific black ...

• Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) is responsible for motor symptoms Parkinson's disease. R-type calcium channels have been linked to selective vulnerability nigral an animal model Immunohistochemistry was used examine CAV2.3 expression human brains. In disease patients higher than those neighbouring ventral tegmental area and control might be therapeuti...

Submit Manuscript | http://medcraveonline.com LC: Locus Coeruleus; LHA: Lateral Hypothalamic Area; MLR: Midbrain Locomotor Region; NAc: Nucleus Accumbens; NRGc: Nucleus Reticularis Gigantocellularis; NRMc: Nucleus Reticularis Magnocellularis; ORX: Orexin; PD: Parkinson’s Disease; PM: Premotor Area; PMRF: Pontomedullary Reticular Formation; PPN: Pedunculopontine Tegmental Nucleus; PRF: Pontine R...

The morphology and connections of the accessory nucleus of Luys were examined in male Wistar strain rats using normal materials stained for Nissl or myelin sheath, and employing the horseradish peroxidase (HRP) method. This nucleus is situated ventrocaudally to the subthalamic nucleus and rostrally to the substantia nigra. The cells of the nucleus were stained more faintly than those of the sub...

Submit Manuscript | http://medcraveonline.com LC: Locus Coeruleus; LHA: Lateral Hypothalamic Area; MLR: Midbrain Locomotor Region; NAc: Nucleus Accumbens; NRGc: Nucleus Reticularis Gigantocellularis; NRMc: Nucleus Reticularis Magnocellularis; ORX: Orexin; PD: Parkinson’s Disease; PM: Premotor Area; PMRF: Pontomedullary Reticular Formation; PPN: Pedunculopontine Tegmental Nucleus; PRF: Pontine R...