A series of 1,3-diarylprop-2-en-1-one oximes (7-12) were synthesized via reaction (1-6) with NH2OH. HCl in dry pyridine. In order to produce the required products (13-18) as anti-isomers, these (7–12) then treated acetic anhydride Different substitutes are maintained, resulting separation different yields The recently produced esters thought be useful building blocks for synthesis substituted p...

The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various a...

A concise one-pot synthesis of highly functionalized pyridines has been developed. The first step in the reaction sequence is the formal insertion of rhodium vinylcarbenoids across the N-O bond of isoxazoles. Upon heating, the insertion products undergo a rearrangement to give 1,4-dihydropyridines. DDQ oxidation then affords the corresponding pyridines in 31-84% yield. The process has proven ge...

The divalent metal ions, Mg2+ and Ca”, catalyze the reaction of p-nitrophenyl phosphate dianion (PNPP) with substituted pyridines but do not increase the associative character of the transition state, as indicated by values of p,,, in the range 0.17-0.21 for PNPP and for its metal ion complexes. The reactions of phosphorylated morpholinopyridine (MPP) are inhibited approximately twofold by Mg2+...