Abstract Background A nondepolarizing neuromuscular blocking agent (NMBA) with a succinylcholine-like quick onset and offset has been the holy grail of science blockade. Although this drug is still elusive, advent promising new combinations like rocuronium–sugammadex gantacurium– l -cysteine may achieve same end result. The type NMBA; type, timing, dose their reversal drugs; means monitoring NM...

The objective – to summarize the current literature data on etiology, pathogenesis, diagnosis and treatment of malignant hyperthermia. search analysis hyperthermia in medical information systems PubMed, Сochrane librarу, Cyberleninka for last 10 years was performed with using keywords: «malignant hyperthermia», «dantrolene», «general anesthesia», «succinylcholine», «inhalation anesthetics». cri...

Background: Succinylcholine is the most anesthetic drug used to muscle relaxation in emergency endotracheal intubation. Unfortunately it can have serious side effects. The perpose of our study was to comparison of Atracurium + Alfentanyl with succycholine. Materials and Methods: In this clinical trial study, one hundred patient randomly designated two group succinylcholine (control group) & At...

In a prospective, double-blind placebo controlled trial, the effect of oral diazepam premedication on post-succinylcholine fasciculations and myalgia was studied. Forty patients undergoing septoplasty procedures received orally identical capsules containing either 10 mg of diazepam or a placebo 90 minutes preoperatively. A standardized anaesthetic regimen included induction with 5 mg X kg-1 of ...

Succinylcholine chloride is a potent relaxant of voluntary striated muscle but has little direct effect on smooth muscle. It has no anesthetic or pain-obliterating properties; therefore, immobilized animals remain completely conscious although unable to move. The duration of effect is quite brief because succinylcholine is rapidly destroyed by non-specific cholinesterases in the blood plasma an...

TOPIC: Critical Care TYPE: Fellow Case Reports INTRODUCTION: Succinylcholine, a depolarizing muscular blocker, has widespread use for rapid sequence intubation (RSI) in the intensive care unit (ICU), emergency department, and operating room. The advantageous pharmacologic profile includes onset of action (40-60 secs), short duration (6-10 mins), better conditions such as ease laryngoscopy diaph...

To the Editor: Alfentanil is a new narcotic capable of blunting intraoperalive haemodynamic responses while allowing for return of spontaneous ventilation and consciousness after short surgical procedures. We have recently noted reports of severe bradycardia with the use of alfentanil combined with succinylcholine, t,2 We also present such a case. A 76-year-old 45 kg woman was scheduled for rem...

Myasthenia Gravis is autoimmune disorder of neuromuscular transmission. In some cases, psychiatric complications aggravate its course. Myasthenia gravis (MG) has always been a challenge for anesthesiologists and psychiatrists when the use of electroconvulsive therapy (ECT) is required, especially when succinylcholine is used together with acetylcholinesterase inhibitors. We describe a 76 years ...

The effects on muscle fasciculations and ease of tracheal intubation of pretreatment with fazadinium before administration of succinylcholine were evaluated in 85 patients. Four dose levels of fazadinium evaluated were 0.05 mg . kg-1, 0.075 mg . kg-1, 0.10 mg . kg-1 and 0.15 mg . kg-1. The 0.05 mg . kg-1 dose did not always prevent succinylcholine-induced muscle fasciculations. The 0.15 mg . kg...

4.5. Bisbenzyl-isoquinolinium compounds 4.5.2. Mivacurium 4.6. Reversal of non-depolarizing neuromuscular block by anticholinesterases 4.7. Other neuromuscular uses of anticholinesterases 4.8. Pharmacokinetics of non-depolarizing neuromuscular blocking drugs 4.8.1 Clearance of non-depolarizing neuromuscular blocking drugs and duration of action 5. Depolarizing neuromuscular blocking drugs 5.1. ...