objective(s): in this study, drug loaded electrospun nanofibrous mats were prepared and drug release and mechanism from prepared nanofibers were investigated.  materials and methods: paclitaxel (ptx) loaded polylactic acid (pla) nanofibers were prepared by electrospinning. the effects of process parameters, such as ptx concentration, tip to collector distance, voltage, temperature and flow rate...

background: nowadays, nosocomial infection with multidrug-resistant acinetobacter is an important problem in the world, which is facing wide spectrum antibiotics and hence has become resistant. m aterials and methods: in this study, positive cultures of acinetobacter from one hundred clinical samples in seven hospitals from tehran during 2012-2013 were collected for checking antibiotic suscepti...

introduction cephalic tetanus is a rare form of tetanus, defined as trismus and cranial nerve palsy. it has a mortality rate of 15 - 30%. case presentation the purpose of this case report was to present a case of cephalic tetanus with trismus, a rare form of tetanus, in an intravenous drug abuser. timely diagnosis and management prevented progression into the generalized form and made the patie...

although the conventional therapies have obviously improved the conditions of patients with cancer, some mechanisms of resistance have led scientists to use alternative agents that can penetrate in most solid tumors. furthermore, the success of cancer therapies depends on limiting the uptake of toxins to normal tissues and their selectivity to malignant cells. the involvement of natural and gen...

having conducted fundamental projects, scientists have expressed their hope to develop the use of carbon nanotubes to release drugs. it is important to release drugs in cell without damaging healthy cells of tissues under study. researchers have shown the fact that nanotubes can perform this function perfectly. to this objective, in the present study the interactions between four anti-cancer dr...

interpenetrating polymer networks (ipn) were formed involving hydrophobic polybutyl acrylate (pba) and hydrophilic poly hydroxyethyl acrylate (phea). pba prepolymer was first formed in presence of ferric oxide nanoparticles (

stabilities and quantum molecular descriptors of cyclophoshphamide (an anticancer drug)-functionalized (8,0) zigzag and (4,4) armchair carbon nanotubes (cnts) complexes in water were studied using density functional theory (dft) calculations. two attachments namely the sidewall- and tip-attachments are considered for the model constructions. calculations of the total electronic energy (et) and ...

indications for linezolid use are nosocomial or community-acquired pneumonia and skin infections or soft tissue infection caused by gram-positive microorganisms, but new recommendations may emerge. it is important to balance benefits with risks because severe adverse events have been described in patients taking linezolid treatment. accordingly, we evaluated the suitability of linezolid prescri...