A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, Bel-7402). Among these sulphonamides, compound 17a displayed the best anti-liver Bel-7402 cells with an IC50 value 0.32 μM. Compound could effectively inhibit tubulin polymerisation 1.27 Meanwhile, it selectively suppressed LSD1 63 n...

Thyroid function is known to be affected by many commonly used drugs of varied chemical structures. It is known that substances like sulphonamides, perchlorates, nitrates affect thyroid activity. With the introduction of radio active iodine in experimental and clinical medicine, it has been possible to study critically the effect of drugs on thyroid activity, on the ba-is of iodine uptake by th...