نتایج جستجو برای: super paramagnetic iron oxide
تعداد نتایج: 363312 فیلتر نتایج به سال:
INTRODUCTION The gold standard for detecting organ rejection after transplantation is biopsy, which is not only invasive but also prone to sampling errors. We have been developing and optimizing MRI techniques to assess organ rejection after transplantation by monitoring the accumulation of immune cells at the rejection site using various iron-oxide-based contrast agents [1-3]. There are two sc...
Background Self-navigation (SN) in 3D radial segmented MR imaging [1] has been shown to be an efficient and robust method for depiction of coronary luminal anatomy using MRI. This method has largely been used at 1.5T using SSFP readouts to provide the high blood to myocardium contrast required for vessel segmentation and SN. However, bSSFP imaging is often confounded by off-resonance artifacts ...
This study determines the effect of naked and heparinbased super-paramagnetic iron oxide nanoparticles on the human cancer cell lines of A2780. Doxorubicin was used as the anticancer drug, entrapped in the SPIO-NPs. This study aimed to decorate nanoparticles with heparin, a molecular ligand for ‘active’ targeting of cancerous cells and the application of modified-nanoparticles in cancer treatme...
Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) combined with magnetic resonance imaging (MRI) are under clinical evaluation to enhance detection of neurodegenerative diseases. A major improvement would be to link therapeutic drugs to the SPIONs to achieve targeted drug delivery, either at the cell surface or intracellularly, together with active disease detection, without inducing cell re...
BACKGROUND Long-term survival of heart transplants is hampered by chronic rejection (CR). Studies indicate the involvement of host macrophages in the development of CR; however, the precise role of these cells in CR is unclear. Thus, it is important to develop noninvasive techniques to serially monitor the movement and distribution of recipient macrophages in chronic cardiac allograft rejection...
Electronic states of iron ion complexes in human blood from patients with melanoma have been investigated by electron paramagnetic resonance (EPR). The measurements were performed at liquid nitrogen temperature (77 K) on an X-band EPR spectrometer. Numerous types of iron paramagnetic centers have been identified. In several kinds of protein complexes exemplified by methemoglobin, transferrin or...
Superparamagnetic iron oxide (SPIO) and ultra small superparamagnetic iron oxide (USPIO) nanoparticles have been developed as magnetic resonance imaging (MRI) contrast agents. Iron oxide nanoparticles, that become superparamagnetic if the core particle diameter is ~ 30 nm or less, present R1 and R2 relaxivities which are much higher than those of conventional paramagnetic gadolinium chelates. G...
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