This thesis discusses particle production by supercritical antisolvent processing (SAS) techniques by looking the fundamentals and applications of the method with some case studies. The final aim of this work is however to consider the SAS particle production process feasibility. In the process studied the solid is dissolved in a conventional solvent and the solution is sprayed continuously thr...

Let Ω be a bounded domain in Rn, n ≥ 3 with smooth boundary ∂Ω and a small hole. We give the first example of sign-changing bubbling solutions to the nonlinear elliptic problem −∆u = |u| n+2 n−2+ε−1u in Ω, u = 0 on ∂Ω, where ε is a small positive parameter. The basic cell in the construction is the signchanging nodal solution to the critical Yamabe problem −∆w = |w| 4 n−2w, w ∈ D(R) which has l...

In this work, Monte Carlo simulations have been carried out to investigate the swelling stability and interlayer structures of alkylammonium-modified montmorillonite both in vacuum and in supercritical CO(2) (scCO(2)) fluid. In the vacuum (dry) condition, the stable spacing for this kind of organoclay was determined based on the energy minimum. In the stable spacing, the corresponding interlaye...

Solubilities of some polycyclic aromatic hydrocarbons (PAHs) in supercritical carbon dioxide were measured with a procedure based on a direct on-line combination of a saturation cell to a flame ionization detector. Acenaphthene, anthrance and chrysene were selected as the test solutes. A method was developed and evaluated which enables the measurement of the contribution of solute vapor pressur...

There are two types of application for gas chromatography (GC) in the supercritical fluid extraction process. Gas chromatography is a type of supercritical extraction apparatuses which can separate a component from a multi-component mixture during supercritical extraction. Therefore, this application can be the alternative to conventional gas chromatography, which needs high temperatures for th...

A supercritical fluid (SF) can be defined as a dense non condensable fluid. A fluid reaches the supercritical status when its temperature and pressure exceed the relevant critical temperature and pressure. At the critical point only a single phase exists which has some properties typical of liquids (density) and some of gases (viscosity, compressibility, and mass diffusion coefficient). For pha...

Supercritical fluid chromatography (SFC) was first attempted in 1962 [1]. Although several papers on SFC were published during the subsequent two decades [2], their content did not encourage many researchers to investigate this technique. After the introduction of fused-silica capillary SFC in the early 1980s [3], many papers describing fundamental studies as well as application studies appeare...

We report a rapid one-pot supercritical fluid approach to prepare the desired size and morphology controlled LiMPO(4) nanocrystals, using oleylamine as both capping and reducing agent.

Computational fluid dynamics (CFD) studies can be used for improving the understanding of fluid flow and heat transfer in packed bed systems. The objective of this work was to study the heat effects in packed bed reactor under supercritical conditions using CFD comparing the simulations with empirical correlations. Simulations were done for a geometrical model of packed bed of cylindrical catal...

The multiresistance of bacteria to antibiotics, as well as the lack of new antibiotics on the market encouraged the reasearch of antibacterial activity of non-antibiotic substances including plant extracts. During the previous decades, it has been proven that extracts of certain plants have a strong antibacterial activity, but their clinical use was limited due to the presence of organic solven...