The pharmacokinetics of fluconazole in nine adult patients with severe (30 to 95% total body surface area) burns were studied. There was no significant difference in half-life (t1/2), clearance (CL), or volume of distribution (V) over time in five patients on days 3 and 8 of the study (P > 0.05). Combined parameter estimates (means +/- standard deviations) for all nine patients for the two stud...

This paper presents a new method for surface mesh simplification. Given an initial surface mesh (denoted as reference mesh), the goal is to reduce the number of mesh elements while preserving the geometric approximation as well as the shape quality of the resulting mesh. Two tolerance areas with respect to the reference mesh have been introduced to preserve the geometry of the surface. The refe...

We provided a curve-fit equation to predict the normal heart weight (g) in Koreans by examining 422 autopsies (215 males and 207 females, from newborn to age 77 yr) who were relatively in good general condition. Heart weight was well correlated with body surface area (m2), body weight (kg), and body height (cm) but poorly with age in both sex. Heart weight progressively increased from birth to ...

PERPETUATED To estimate small burn areas, the usual teaching is that the patient’s palm is 1% of body surface area. It has never been very clear whether this means the palm surface of the whole hand or the palm excluding the fingers. This is a source of confusion to many junior doctors. The Advanced Trauma Life Support student manual has been in contradiction to evidence from the literature and...

The unbound serum concentration of valproic acid (VPA) is closely related to its therapeutic efficacy. In epileptic infants, the unbound VPA concentration varies largely from patient to patient, being difficult to predict using the reported equations for older children. To establish an equation to estimate the unbound concentration in infants, we empirically characterized the relationship betwe...

The British National Formulary and many reference textbooks recommend that drug dosages for children be calculated according to body surface area (BSA). Although many rules for drug dosage have been developed, based on age, weight and surface area, none has been accurate and simple enough for routine use. These rules are described, and one for clinical use: up to 30 kg, a child's drug dose may ...

We used state of the art CMR to define ranges for normal left ventricular volumes and systolic/diastolic function normalized to the influence of gender, body surface area and age. New CMR normalized ranges were modeled and displayed in graphical form for clinical use, with normalization for body surface area, gender, and age. The determination of normality, or the severity of abnormality, depen...

A series of body charts have been designed that are more representative of changing body proportion with increasing age. Being easier to use, these charts have led to a better estimate by the casualty doctor of the body surface area that has been burned.

We retrospectively compared body surface area (BSA) using the Mosteller formula square root(H x (w/360)) and a simple weight-based BSA formula ([4Wkg+7]/ [90+Wkg]). The participants were 363 children who underwent cardiac surgery from 1991 to 2000. Their age ranged from 5 days to 18 years, weight ranged from 1.2 kg to 98 kg and height ranged from 38 cm to 178 cm. There was excellent correlation...

OBJECTIVES To report the management of burn injuries that occured in the Syria civil war, which were referred to our burn center. Methods: Forty-three patients with burns, injured in the civil war in Syria and whom were referred to Dr. Lütfi Kırdar Kartal Educating and Training Hospital Burn Centre of İstanbul, Turkey between 2011-2015 were analyzed in a retrospective study. Results: Most of ou...