The effect of in vitro preimplantation exposure of mouse embryos to N-methyl-N-nitrosourea (MNU) on development subsequent to embryo transfer into pseudopregnant surrogate mothers has been investigated. The offspring developed from mouse blastocysts exposed to MNU or to solvent were examined carefully for 1 year after birth and then examined with X-rays and complete autopsies. Metaphase chromos...

In utero hematopoietic cell transplantation (IUHCT) has been performed in Mucopolysaccharidosis Type VII (MPSVII) mice, but a lifelong engraftment of allogeneic donor cells has not been achieved. In this study, we sought to confirm a lifelong engraftment of allogeneic donor cells immunologically matched to the mother and to achieve partial rescue of phenotypes in the original MPSVII strain thro...

A retrospective study was carried out to assess the potential of 16 hysterectomized women to achieve surrogate pregnancies. A total of 11 patients completed 16 cycles of assisted conception treatment incorporating in-vitro fertilization and gestational surrogacy. Three other women failed to respond to ovulation induction while two more patients produced few oocytes which also failed to fertiliz...

This paper presents a discriminating approach to detecting the existence of underlying determinism in speech phonemes using the surrogate data method. The discrimination is made using a statistical measurement of neighboring trajectory directions. This approach is experimentally verified with both deterministic and stochastic time series and then applied to speech phonemes from the TIMIT databa...

We introduce a new correlation-based measure of spike timing reliability. Unlike other measures, it does not require the definition of a posteriori "events". It relies on only one parameter, which relates to the timescale of spike timing precision. We test the measure on surrogate data sets with varying amounts of spike time jitter, and missing or additional spikes, and compare it with a widely...

OBJECTIVES Biological modelling of routinely collected newborn screening data has emerged as a novel method for deriving postnatal gestational age estimates. Validation of published models has previously been limited to cohorts largely consisting of infants of white Caucasian ethnicity. In this study, we sought to determine the validity of a published gestational age estimation algorithm among ...

The natural and surrogate key architectures are two competing approaches to specifying keys in relational databases. We analyze the performance of these approaches with respect to the update complexity and the query data and expression complexity. Our results provide new insights into the advantages and disadvantages of both approaches.

Objective: Duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. Intima media thickness (IMT) is appropriate for atherosclerosis process diagnosis. Leukoaraisis (LA) increase the risk of cerebrovascular accident (CVA). LA patients need preventive medication for CVA. IMT is a non-invasive diagnostic and prognostic test in LA. The aim of this study was evalua...

in surrogate pregnancies genetic parents have little opportunity for early bonding with their infants either prenatally (in utero) or during the immediate postnatal period. procedures commonly used to induce lactation include both pharmacologic and nonpharmacologic methods often in combination. studies reporting induced lactation are sparse due to the rarity of augmented lactation. here we repo...