Benzodiazepine hypnotics (BZDs) have been a popular treatment for insomnia since the 1960s, but they various problematic side effects, including falls and delirium.1, 2 Non-BZDs were developed right after BZDs are BZD receptor agonists (BZD-RAs) in action. In Japan, two other non-BZD-RA released, namely ramelteon (melatonin agonist [MRA]) 2010 suvorexant (orexin antagonist [ORA]) 2014. Despite ...
