Simvastatin (SV) is a lactone prodrug used for the treatment of hypercholesterolemia. Upon incubation of SV with liver microsomal preparations from human donors, four major metabolic products were formed (3'-hydroxy SV, 6'-exomethylene SV, 3',5'-dihydrodiol SV, and the active hydroxy acid, SVA), together with several minor unidentified metabolites. The 3',5'-dihydrodiol SV, a new metabolite, wa...

U radu se daje kratak osvrt na život apostola sv. Filipa i Jakova Mlađega. Sv. Filip najprije je bio učenik Ivana Krstitelja. Po redoslijedu pozivanja peti. Jakov poznat kao Alfejev, brat Gospodinov Pravedni. Mlađi Manji nazivan da bi razlikovao od Zebedejeva, koji po pozivanja, treći apostol. deveti Isusov učenik. Njihov spomendan svetkuje istoga dana jer relikvije Mlađega nalaze uz u crkvi Do...

R. Brossier, J. Virieux and S. Operto 1 Géosciences Azur, Université de Nice Sophia-Antipolis, CNRS,IRD, Université Pierre et Marie Curie, Valbonne, France. E-mail: [email protected]. 2 Laboratoire de Géophysique Interne et Tectonophysique, Université Joseph Fourier, CNRS, Grenoble, France. E-mail: [email protected]. 3 Géosciences Azur, Université de Nice Sophia-Antipolis...

Sedentary time and screen-viewing (SV) are associated with chronic disease risk in adults. Parent and child sedentary time and SV are associated. Parents influence children's SV through parenting styles and role modelling. Understanding whether parents' attitudes toward child SV are associated with their own SV and sedentary time will aid development of family interventions to reduce sedentary ...

OBJECTIVE To investigate liver lobe volumes and the ratios of liver lobe volumes to spleen volume measured with magnetic resonance imaging (MRI) for quantitatively monitoring and staging liver fibrosis. METHODS Animal study was approved by Institutional Animal Care and Use Committee. Sixteen minipigs were prospectively used to model liver fibrosis, and underwent abdominal gadolinium-enhanced ...

Background: Antiepileptic drugs, such as sodium valproate (SV), are teratogenic as their usage by the pregnant mother has been associated with an increased risk of major congenital abnormalities in the fetus. In this study, the effects of voluntary exercise and prenatal exposure to SV on learning, memory, and anxiety in rats’ offspring are investigated.Methods: In the present study, 70 fe...

BACKGROUND Intermediate- to-high-risk prostate cancer can locally invade seminal vesicle (SV). It is recommended that anatomic proximal 1-cm to 2-cm SV be included in the clinical target volume (CTV) for definitive radiotherapy based on pathology studies. However, it remains unclear whether the pathology indicated SV extent is included into the CTV defined by current guidelines. The purpose of ...

Artificially mediated linear (methylviologen) and cyclic (phenazine methosulfate) electron transport induced zeaxanthin-dependent and independent (constitutive) nonphotochemical quenching in osmotically shocked chloroplasts of pea (Pisum sativum L. cv Oregon). Nonphotochemical quenching was quantitated as Stern-Volmer quenching (SV(N)) calculated as (F(m)/F'(m))-1 where F(m) is the fluorescence...

BACKGROUND To analyze interfraction motion of seminal vesicles (SV), and its motion relative to rectal and bladder filling. METHODS AND MATERIALS SV and prostate were contoured on 771 daily computed tomography "on rails" scans from 24 prostate cancer patients undergoing radiotherapy. Random and systematic errors for SV centroid displacement were measured relative to the prostate centroid. Mar...