Hepatitis C virus (HCV) genotype 3 is responsible for 30.1% of chronic hepatitis C infection cases worldwide. In the era of direct-acting antivirals, these patients have become one of the most challenging to treat, due to fewer effective drug options, higher risk of developing cirrhosis and hepatocellular carcinoma and lower sustained virological response (SVR) rates. Currently there are 4 reco...

BACKGROUND Genome-wide association studies have recently revealed that several single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 28B genes can predict the sustained virological response (SVR) to pegylated interferon-α2a/b plus ribavirin in hepatitis C virus (HCV)-genotype 1 patients. However, data for patients infected with HCV genotype 4 (HCV-G4) are limited. AIM We analyzed the...

Few studies have conducted follow-up investigations of the clinical course in HCV-related cirrhotic patients who achieved a sustained virological response (SVR) with pegylated interferon plus ribavirin treatment (PegIFN + RBV). We investigated the clinical course and laboratory data in a prospective cohort study enrolling HCV-related cirrhotic patients who received PegIFN + RBV between August 2...

AIMS We aimed to examine changes in skeletal muscle mass in chronic hepatitis C (CHC) patients undergoing interferon (IFN)-free direct acting antivirals (DAAs) therapy who achieved sustained virological response (SVR). PATIENTS AND METHODS A total of 69 CHC patients treated with DAAs were analyzed. We compared the changes in skeletal muscle index (SMI) using bio-impedance analysis at baseline...

Stock market price index prediction is regarded as a challenging task of the financial time series prediction process. Support vector regression (SVR) has successfully solved prediction problems in many domains, including the stock market. This paper hybridizes SVR with the self-organizing feature map (SOFM) technique and a filter-based feature selection to reduce the cost of training time and ...

Electricity load forecasting is an important issue that is widely explored and examined in power systems operation literature and commercial transactions in electricity markets literature as well. Among the existing forecasting models, support vector regression (SVR) has gained much attention. Considering the performance of SVR highly depends on its parameters; this study proposed a firefly alg...

Direct-acting antivirals (DAAs) in combination with pegylated IFN-a and ribavirin drastically improve the rates of rapid virological response (RVR) and sustained virological response (SVR) in the treatment of chronic hepatitis C virus infection, specifically in difficult-to-cure hepatitis C virus genotype 1. At present, RVR is an important milestone highly predictive of SVR. Response-guided the...

Recently, Support Vector Regression (SVR) has been introduced to solve regression and prediction problems. In this paper, we apply SVR to financial prediction tasks. In particular, the financial data are usually noisy and the associated risk is time-varying. Therefore, our SVR model is an extension of the standard SVR which incorporates margins adaptation. By varying the margins of the SVR, we ...

Due to the complexity and high non-linearity of bioprocess, most simple mathematical models fail to describe the exact behavior of biochemistry systems. As a novel type of learning method, support vector regression (SVR) owns the powerful capability to characterize problems via small sample, nonlinearity, high dimension and local minima. In this paper, we developed a ν-SVR model with genetic al...

Music emotion plays an important role in music retrieval, mood detection and other music-related applications. Many issues for music emotion recognition have been addressed by different disciplines such as physiology, psychology, cognitive science and musicology. We present a support vector regression (SVR) based music emotion recognition system. The recognition process consists of three steps:...