Introductory points. We have read the comments by D’Ambrosio and colleagues, including their supplemental material; these comments have not changed our interpretation of our data (or theirs) or our conclusions. We stand fully behind our paper, as published. (1) We believe all aspects of our experimental design were completely appropriate for studying epileptogenesis; the experimental techniques...

s are only included if they are not published later on in full article format. Abbreviations: IED,interictal epileptiform discharges; VNS, vagus nerve stimulation; 3-MPA, 3-mercaptoproprionate;PTZ, pentylenetetrazol; MES, maximal electroshock seizure; SWDs, spike and wave discharges; ADD,afterdischarge duration. Zanchetti et al. (1952) were among the first to experiment with the ant...