Hyponatremia is a clinically relevant disorder. Ten to twenty per cent of patients in hospitals are affected by it. Hyponatremia is found to occur in almost every clinical department. Recently, vasopressin antagonists have been licensed to treat hyponatremia of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). They provide physicians with the first specific and effective the...

The purpose of this study was to determine the efficacy and safety tolvaptan in Japanese patients with hyponatremia secondary syndrome inappropriate secretion antidiuretic hormone (SIADH). This multicenter, open-label, dose-escalation, phase III enrolled (20–85 years old) SIADH who were unresponsive fluid restriction. Oral administered for up 30 days, initially at 7.5 mg/day, but escalated dail...

Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a frequent cause of hypotonicity. Although the differential diagnosis with other causes of hypotonicity such as salt depletion is sometimes challenging, some simple and readily available biologic parameters can be helpful in the diagnosis of SIADH. In SIADH, urea is typically low; this is less s...

Hyponatraemia is a common finding in patients with acute cerebral insults. The main differential diagnosis is between syndrome of inappropriate ADH secretion and cerebral salt wasting. Our aim is to review the topic of hyponatraemia in patients with acute cerebral insults and suggest a clinical approach to diagnosis and management.

Hyponatraemia is a common finding in patients with acute cerebral insults. The main diVerential diagnosis is between syndrome of inappropriate ADH secretion and cerebral salt wasting. Our aim is to review the topic of hyponatraemia in patients with acute cerebral insults and suggest a clinical approach to diagnosis and management. (Arch Dis Child 2001;85:246–251)

Recurrent manic-like episodes can be induced by hyponatremia possibly due to empty sella syndrome. In the present case, the patient was proven to have syndrome of inappropriate antidiuretic hormone (SIADH) secretion with manic symptoms that resolved after the normalization of the plasma sodium level.To our knowledge, this is the first case of hyponatremia-induced manic symptoms in a patient wit...

Acute intermittent porphyria (AIP) is a rare condition characterized by abdominal pain and a wide range of nonspecific symptoms. We report the case of a 24-year-old woman with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and motor and sensory neurological deficits due to an attack of acute porphyria. The patient presented to the emergency department with abdominal pain. T...

Hyponatremia is a marker of different underlying diseases and it can be a cause of morbidity itself; this implies the importance of a correct approach to the problem. The syndrome of inappropriate antidiuresis (SIAD) is one of the most common causes of hyponatremia: it is a disorder of sodium and water balance characterized by urinary dilution impairment and hypotonic hyponatremia, in the absen...

BACKGROUND Hyponatremia occurring as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or cerebral salt wasting syndrome is a common complication in patients with subarachnoid hemorrhage (SAH). The efficacy and safety of urea as treatment for SIADH-induced hyponatremia has not been reported in this population. METHODS This is a retrospective analysis of all pati...