OBJECTIVE To investigate anti-apoptogenic mechanism of transforming growth factor beta1 (TGFbeta1) towards synovial cells. METHODS Isolated synovial cells, treated or not with TGFbeta1, were cultured in the presence or absence of anti-Fas IgM, proteasome inhibitor Z-Leu-Leu-Leu-aldehyde (LLL-CHO), etoposide, or C2-ceramide. After cultivation, apoptosis of synovial cells was examined by the pr...

Synovial fluid cells from joints of rheumatoid arthritis (RA) patients express a novel variant of CD44 (designated CD44vRA), encoding an extra trinucleotide (CAG) transcribed from intronic sequences flanking a variant exon. The CD44vRA mutant was detected in 23 out of 30 RA patients. CD44-negative Namalwa cells transfected with CD44vRA cDNA or with CD44v3-v10 (CD44vRA wild type) cDNA bound FGF-...

1. The cartilage-proteoglycan-degrading activity of synovial fluid cells from rheumatoid patients is primarily due to neutral protease activity; hyaluronidase does not contribute significantly. Evidence for these conclusions is adduced from electrophoresis of degradation products, from comparison of the proteoglycan-degrading and protease activities of extracts and from the effects of activator...

introduction: malignant mesenchymal tumors of the larynx are rare. one type of malignant mesenchymal tumor is synovial sarcoma with unknown histogenesis, which occurs predominantly in the lower extremities of young adults. the head and neck region is a relatively rare location. there are few cases of malignant mesenchymal tumors with laryngeal localization in literature.  case report: in this r...

Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic joint inflammation. The precise aetiology of this autoimmune process remains unclear. Soluble factors produced by infiltrating synovial cells play an important role in driving the inflammatory process that leads to inflammatory cell migration and proliferation in the synovial tissue. These soluble factors consist mainly...

Iron dcxtran (molecular weight 7,000) diffuses rapidly from the joint cavity through the synovium, along lymphatics and cxtraccllular tissuc spaces; articular cartilagc is impermeable to iron dextran. Thcre is also rapid cellular uptake by synovial lining cells, particularly of the vacuolar type; cndoplasmic reticulum-containing lining cells rarely take up iron dextran. Cellular uptake is proba...

Analyzing the synovial fluid is one of the common methods to diagnose the articular problems to detect the stage and express the prognosis. Such gross, cytological, and biochemical analysis of synovial fluids can aid in the diagnosis of various joint diseases. Objectives: Normal values for synovial fluid in the camels have been described previously; however, there are no reports regarding conce...

INTRODUCTION Mast cells have been implicated to play a functional role in arthritis, especially in autoantibody-positive disease. Among the cytokines involved in rheumatoid arthritis (RA), IL-17 is an important inflammatory mediator. Recent data suggest that the synovial mast cell is a main producer of IL-17, although T cells have also been implicated as prominent IL-17 producers as well. We ai...

To investigate the role of macrophages as a regulator and producer of nerve growth factor (NGF) in the synovial tissue (ST) of osteoarthritis (OA) joints, the gene expression profiles of several inflammatory cytokines in the ST, including synovial macrophages and fibroblasts, of OA mice (STR/Ort) were characterized. Specifically, real-time polymerase chain reaction analysis was used to evaluate...

RA is characterized by massive proliferation of synovial tissue, accompanying infiltration of the tissue with CD4+ T lymphocytes, and a genetic linkage to the MHC antigen HLA-DR4. Since T cells are restricted by class II MHC molecules such as DR4, this suggests a direct role for these CD4+ cells in pathogenesis. To investigate T cell receptor (TCR) usage in RA, we used oligonucleotide primers s...