This study investigated the effect of combined seeds Sesemum indicum (SI) and Moringa oleifera (MO) on liver function markers in alloxan-induced diabetic albino rats. 54 rats were divided into 9 groups 6 animals each. Group 1 served as normal control received standard feed diet, 2 (Diabetic control) intraperitoneal injection 140mg/kg Alloxan, 3 (Positive 5mg/kg glibenclamide, 4; fed diet contai...

This study aimed to evaluate the effect of Hibiscus sabdariffa L. dried calyx ethanolic (HSE) extract on redox imbalance and glucose plasma vitamin B12 restriction Sprague-Dawley rats. The rat was fed a Vitamin Restriction Diet for 16 weeks treated with HSE as treatment group. One group diet not positive control group, another chow negative B12, MDA, SOD activity enzyme, levels were evaluated i...

BACKGROUND Obesity is a disease involving body weight gain. Several synthetic drugs of better efficacy are being introduced in the modern system of medicine. Orlistat is a pharmacological agent promoting weight loss in obese subjects via inhibiting of gastric and pancreatic lipase. Ginger (Zingiber officinale Roscoe, Zingiberacae) is one of the most commonly used spices around the world; it has...

Effects of quantity and quality of dietary proteins on plasma immunoreactive insulin-like growth factor-1 (IGF-1) concentration, and content of IGF-1 mRNA in rat liver were investigated in rats. Plasma immunoreactive IGF-1 concentration in rats given a casein diet was higher than that in rats given a soya-bean-protein or protein-free diet. The IGF-1 mRNA content in liver was estimated by the No...

Objective(s) PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and liver samples were obtained. In hyperglycemic rat, 0.5 g/kg glucose with o...

Aim: To induce rat model of hyperlipidemia through high fat diet feeding, exploring the effect of abnormal lipid metabolism in rat leydig cell testosterone biosynthesis and proliferation. Methods: 30 healthy male SD rats were randomly divided into normal group (NG) and the obese group (OG). Rats in NG were fed with basic diet, while rats in OG were continuously fed with high fat diet for 16 wee...

Vitamin E, the most potent antioxidant in the lipid phase, was tested for antiinflammatory activity in trinitrobenzenesulfonic acid-induced rat colitis. Rats were fed a nonpurified diet (saline and control groups) or a vitamin E supplemented diet (treated group, 300 mg/kg nonpurified diet). Vitamin E supplementation, which resulted in increased colonic vitamin E levels, reduced colonic weight a...

Ubiquitin is a crucial post-translational modification regulating numerous cellular processes, but its role in metabolic disease is not well characterized. In this study, we identified the in vivo ubiquitin-modified proteome in rat liver and determined changes in this ubiquitome under acute insulin stimulation and high-fat and sucrose diet-induced insulin resistance. We identified 1267 ubiquiti...