The attachment of biotin to a small molecule provides a powerful tool in biology. Here, we present a systematic approach to identify biotinylated analogues of the Hsp90 inhibitor PU-H71 that are capable of permeating cell membranes so as to enable the investigation of Hsp90 complexes in live cells. The identified derivative 2g can isolate Hsp90 through affinity purification and, as we show, rep...

This essay provides an introduction to the terminology, concepts, methods, and challenges of image-based modeling in biology. Image-based modeling and simulation aims at using systematic, quantitative image data to build predictive models of biological systems that can be simulated with a computer. This allows one to disentangle molecular mechanisms from effects of shape and geometry. Questions...

Scholars have debated whether virtual laboratories are educationally effective tools and if they should be continuously developed. In this paper, we comprehensively review literature about the effectiveness of labs in teaching learning biology to identify topics often taught linked outcomes. We used Google Scholar, ERIC, Web Science electronic databases access journal articles conference procee...

<p style="text-align: justify;">A large number of articles in the field science education reflect on scientific literacy as main goal (SE), although often with varying viewpoints. Nevertheless, researchers have begun to highlight subject-specific teaching practices that are expected specifically enhance subject teaching, including biology. The aim this theoretical article is come consensu...

This chapter provides a review of recent advances in understanding the importance of alternative pre-messenger RNA splicing in stem cell biology. The majority of transcribed pre-mRNAs undergo RNA splicing where introns are excised and exons are juxtaposed to form mature messenger RNA sequences. This regulated, selective removal of whole or portions of exons by alternative splicing provides aven...

Biomodel engineering is the science of designing, constructing and analyzing computational models of biological systems. It forms a systematic and powerful extension of earlier mathematical modeling approaches and has recently gained popularity in systems biology and synthetic biology. In this brief review for systems biologists and computational modelers, we introduce some of the basic concept...

Systematic Biology Publication details, including instructions for authors and subscription information: http://www.informaworld.com/smpp/title~content=t713658732 The Adequacy of Morphology for Reconstructing the Early History of Placental Mammals Mark S. Springer a; Angela Burk-Herrick a; Robert Meredith a; Eduardo Eizirik b; Emma Teeling c; Stephen J. O'Brien d; William J. Murphy e a Departme...

Biology learning is a field of science that requires students to think critically, creatively, and analytically in order solve problems each material they study. It important for have the right strategies learning, teachers as professionals who teach must be able develop effective efficient students. According various research, implementation STEM (Science, Technology, Engineering, Mathematics)...

Robust stabilization and environmental disturbance attenuation are ubiquitous systematic properties that are observed in biological systems at many different levels. The underlying principles for robust stabilization and environmental disturbance attenuation are universal to both complex biological systems and sophisticated engineering systems. In many biological networks, network robustness sh...