Background During the first months of Sars-CoV-2 pandemic, antimalarial drugs were central axis treatment patients with acute respiratory infection. After that, several studies reported a risk prolongation corrected QT interval (QTc) at electrocardiogram (ECG). Historically, these drugs, have been common denominator in Systemic Lupus Erythematosus (SLE). Objectives To analyze possible relations...

Conventional cancer therapy has many drawbacks because of the high drug dose, systemic toxicity and lacking potential targeting output. The applications of nanotechnology for cancer therapy have been shown to overcome the limitation associated with conventional treatments. It plays a pivotal role by delivering cancer drugs in a sustained and targeted manner to the malignant tumour cells, thereb...

Systemic antifungal agents and their use for the therapy of invasive mycoses are discussed in this chapter. Many of these agents can also be used to treat the mucocutaneous forms of candidiasis, but those uses are discussed in detail in Chapter 257 and thus are mentioned only in passing here. Similarly, the therapy of the various forms of tinea and onychomycosis with topical agents or systemic ...

A 33-year-old man was treated with systemic steroids for a retinal inflammatory lesion before the diagnosis of cryptococcal retinitis and meningitis was suspected. He died from central nervous system disease despite treatment with parenteral antifungals. Histopathological studies demonstrated ocular and disseminated systemic infection with Cryptococcus neoformans. Direct cryptococcal involvemen...

Many different receptors, ion channels, are involved in the pathophysiology of pain, which can serve as targets for adjuvant drugs. Despite advent long-acting local anesthetics, improvement their pharmacokinetics, and advanced regional anesthesia techniques, they do not fully meet need treatment especially chronic pain. In parallel with increase anesthetic power risk systemic toxicity increases...