PURPOSE To develop a method for quantifying left ventricular (LV) internal flow as a measure of dyssynchrony using standard cine cardiac magnetic resonance (CMR) images. MATERIALS AND METHODS CMR images were obtained from 10 healthy controls and 10 patients with dyssynchronous heart failure (class III/IV, LV ejection fraction <35%, pattern seen in an electrocardiogram QRS duration > 150 msec)...

BACKGROUND AND IMPORTANCE Hemodynamics play an important role in the mechanisms of aneurysm formation, growth, and rupture. However, little is known about the hemodynamics of rupture sites. CLINICAL PRESENTATION We incidentally acquired 3-dimensional images before and at the moment of rebleeding of a cerebral aneurysm in a patient. Comparison of these 2 images enabled precise identification o...

was determined from high-speed simultaneous recordings of the electrocardiogram, phonocardiogram, apexcardiogram, and carotid pulse. Data were obtained on children 1 mo to 13 years of age and analyzed to define the independent effects of aging and heart rate on the systolic intervals. Electromechanical systole (Q-II) was found to prolong with increasing age in children with the same heart rate....

The mode of inspiratory augmentation (1A) of the A2-P2 interval was investigated in seven normal volunteers (group 1) and six patients with pulmonary hypertension of diverse etiology (group 2) using catheter-tip micromanometers. In group 1 subjects, inspiratory widening of this interval was found to average 27.2 msec, of which 7.6 plus or minus 2.7 msec (1 sd) or 27 plus or minus 7% was due to ...

BACKGROUND Two-dimensional (2D) perfusion cardiovascular magnetic resonance (CMR) remains limited by a lack of complete myocardial coverage. Three-dimensional (3D) perfusion CMR addresses this limitation and has recently been shown to be clinically feasible. However, the feasibility and potential clinical utility of quantitative 3D perfusion measurements, as already shown with 2D-perfusion CMR ...

Methods 12 healthy controls (age 9-53 years) and 8 patients (age 8-37 years) with a corrected atrioventricular septal defect and a mean mitral valve regurgitation of 25% (range 1937%) were included. The maximal left atrial volume (LAV) was calculated based on the biplane area-length method from a standardized 2and 4-chamber view. Whole-heart 4D Flow MRI was performed on a 3T MR scanner with fre...

BACKGROUND Through ventricular interdependence, pulmonary hypertension (PH) induces left ventricular (LV) dysfunction. We hypothesized that pediatric PH patients have LV diastolic dysfunction, related to adverse pulmonary hemodynamics, leftward septal shift, and prolonged right ventricular systole. METHODS AND RESULTS Echocardiography was prospectively performed at 2 institutions in 54 pediat...